Clinical and histological features of'mechanic's hands' in a patient with antibodies to Jo-1—a case report

The clinical and histological features of‘mechanic's hands' are described in a patient with polymyositis characterized serologically b6y antibodies to histidyl t RNA synthetase (Jo-1). Although distinctive cutaneous lesions have only recently been associated with the ‘anti-synthetase syndrome’. It is becoming apparent that recognition of subsets within the spectrum of polymyositis/dermatomyositis characterized by certain clinical and serological features not only have prognostic significance, but also may provide insights into mechanisms of disease.