| 姜黄素降低短暂性脑缺血再灌注损伤的炎症反应 |
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| 引用本文： | 赵敬,Shanshan Yu,Li Lan,Lin Xuemei,Zhao Yong. 姜黄素降低短暂性脑缺血再灌注损伤的炎症反应[J]. 中国神经再生研究, 2011, 6(3): 219-223 |
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| 作者姓名： | 赵敬 Shanshan Yu Li Lan Lin Xuemei Zhao Yong |
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| 作者单位： | Department of Pathophysiology, Chongqing Medical University, Chongqing 400016, China,Department of Pathology, Chongqing Medical University,Chongqing 400016,China,Department of Pathophysiology, Chongqing Medical University, Chongqing 400016, China,Department of Pathology, Chongqing Medical University, Chongqing 400016, China,Department of Pathology, Chongqing Medical University, Chongqing 400016, China |
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| 基金项目： | the National Natural Science Foundation of China,No. 30900457 |
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| 摘 要： | ![]()
Inflammatory reactions are important pathophysiological mechanisms of ischemic brain injury.The present study analyzed the anti-inflammatory characteristics of curcumin via myeloperoxidase activity and nitric oxide content after 2-hour ischemia/24-hour reperfusion in Sprague Dawley rats.In addition,expressions of nuclear factor kappa B,tumor necrosis factor-α and interleukin-1β protein were measured.Curcumin significantly reduced myeloperoxidase and nitric oxide synthase activities and suppressed expressions of nuclear factor kappa B,tumor necrosis factor-α,and interleukin-1β in ischemia/reperfusion brain tissue.Results suggested that the neuroprotective effect of curcumin following cerebral ischemia/reperfusion injury could be associated with inhibition of inflammatory reactions.
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| 关 键 词： | curcumin inflammation tumor necrosis factor-α nuclear factor kappa B neuroprotection stroke ischemia/reperfusion |
Curcumin reduces inflammatory reactions following transient cerebral ischemia/reperfusion injury |
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| Jing Zhao,Shanshan Yu,Lan Li,Xuemei Lin,Yong Zhao. Curcumin reduces inflammatory reactions following transient cerebral ischemia/reperfusion injury[J]. Neural Regeneration Research, 2011, 6(3): 219-223 |
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| Authors: | Jing Zhao Shanshan Yu Lan Li Xuemei Lin Yong Zhao |
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| Affiliation: | Department of Pathophysiology, Chongqing Medical University, Chongqing 400016, China,,Department of Pathophysiology, Chongqing Medical University, Chongqing 400016, China,Department of Pathology, Chongqing Medical University, Chongqing 400016, China,Department of Pathology, Chongqing Medical University, Chongqing 400016, China |
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| Abstract: | ![]()
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