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| 大鼠气管内灌注三氧化二砷诱发肺癌实验研究 | |
| 引用本文： | 毕文芳 皇德威. 大鼠气管内灌注三氧化二砷诱发肺癌实验研究[J]. 卫生研究, 1989, 18(6): 7-9 |
| 作者姓名： | 毕文芳 皇德威 |
| 作者单位： | 中国预防医学科学院劳动卫生与职业病研究所，中国预防医学科学院劳动卫生与职业病研究所，吉林省卫生防病中心劳动卫生研究所，吉林省卫生防病中心劳动卫生研究所 |
| 摘 要： | 采用雌雄成年Wistar大鼠250只,分为5组:三氧化二砷高、低浓度组(0.4mg/次和0.25mg/次)、空白、生理盐水和阳性对照组。三氧化二砷气管内灌注,每周一次,共10次。实验期限为二年。各组动物诱发肺癌结果分别为3/32(9.4％);1/45(2.2％);0/41;0/34和4/31(12.9％)。 |
| 关 键 词： | 三氧化二砷 肺癌 大鼠 |
Lung Cancer Induced in Rats by Intratracheal Instillation of Arsenous Oxide |
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| Bi Wenfang,Huang Mingfang,Huang Dewei and Jia Baoyuan. Lung Cancer Induced in Rats by Intratracheal Instillation of Arsenous Oxide[J]. Journal of hygiene research, 1989, 18(6): 7-9 | |
| Authors: | Bi Wenfang Huang Mingfang Huang Dewei Jia Baoyuan |
| Affiliation: | Bi Wenfang,Huang Mingfang,Huang Dewei~* and Jia Baoyuan~* |
| Abstract: | 250 adult Wistar rats of two sexes (body weight 180～220g) were used in the study. The rats were divided into five groups and instilled with the following substances: 1. Arsenous oxide(0.4mg/once); 2. Arsenous oxide (0.25mg/once); 3. Physiological saline(0.2ml/once); 4. Natural control group; 5. 3-MCA(10mg, only one time) as positive control group. The rats were anesthesized with ethyl ether and instilled with 0.2ml physiological saline solution mixed with arsenous oxide intratracheally, once a week, a tolal of ten times. The time limit of experiment is for two years. The result showed that the lung cancer incidence of each group was 3/32 (9.4％), 1/45(2.2％), 0/41, 0/34, 4/31 (12.9％) respectively. Statistically, there was significant difference between 3-MCA,As203 high dose group and natural group, P<0.05. |
| Keywords: | arsenous oxide lung cancer rat |
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