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Rescue haploidentical peripheral blood stem cell transplantation for engraftment failure: a single‐centre case series |
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| Authors: | Ian Bilmon John Kwan Emily Blyth Ken Micklethwaite Shyam Panicker Abir Bhattacharyya Stephanie Deren Vicki Antonenas Gillian Huang David Gottlieb |
| Affiliation: | 1. Blood and Marrow Transplant Unit, Westmead Hospital, Sydney, New South Wales, Australia;2. Sydney Cellular Therapies Laboratory, Sydney, New South Wales, Australia;3. Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia |
| Abstract: | Graft failure affects approximately 5% of allogeneic stem cell transplants, with a poor prognosis. Salvage second allogeneic stem cell transplantation (alloSCT2) is limited by high rates of transplant‐related mortality from infection and graft‐versus‐host disease. We report on five adult patients receiving rescue alloSCT2 using haploidentical peripheral blood stem cells. All patients achieved neutrophil engraftment, two subsequently died from sepsis and disease relapse, respectively. Three patients remain alive up to 2 years post‐transplant. We suggest consideration of haploidentical alloSCT2 for patients with graft failure. |
| Keywords: | allogeneic stem cell transplant graft failure haploidentical transplant peripheral blood stem cells graft‐versus‐host disease |