| 曲唑酮与阿米替林治疗抑郁症的双盲对照试验 |
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| 引用本文： | 曾昭祥. 曲唑酮与阿米替林治疗抑郁症的双盲对照试验[J]. 中国健康心理学杂志, 2001, 9(2): 143-145 |
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| 作者姓名： | 曾昭祥 |
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| 作者单位： | 中国.山东省济宁市精神病防治院 |
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| 摘 要： | 目的 评估曲唑酮治疗抑郁症的效果。方法 应用曲唑酮 (男性 1 3例 ,女性 6例 ;年龄 3 6.2± 1 3 .7岁 )与阿米替林(男性 1 1例 ,女性 8例 ,年龄 3 4 .6± 1 2 .5岁 )治疗抑郁症 3 8例 ,并进行随机双盲对照。初始剂量均为 50 mg/日 ,PO,1 0日内渐增至 1 50～ 3 0 0 mg/日 ,观察 6周。采用 HAMD、HAMA及 TESS量表评定。结果 曲唑酮与阿米替林疗效相仿。HAMD总分及其因子分 ,HAMA评分疗后均比疗前显著降低 ,但 2组间比较 ,差别均无显著意义 (P>0 .0 5)。曲唑酮的主要不良反应为镇静 ,其对植物神经及心血管方面的影响明显较阿米替林为轻。结论 曲唑酮是一种安全有效的抗抑郁药
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| 关 键 词： | 曲唑酮 阿米替林 抑郁症 |
| 修稿时间： | 2000-10-30 |
A Double-blind Controlled Clinical Trial of Trazodone vs Amitriptyline in Treating Depression |
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| ZENG Zhaoxiang. A Double-blind Controlled Clinical Trial of Trazodone vs Amitriptyline in Treating Depression[J]. china journal of health psychology, 2001, 9(2): 143-145 |
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| Authors: | ZENG Zhaoxiang |
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| Affiliation: | Zeng Zhaoxiang.Jining Hospital for Preventiion and Treatment of Psychiatric Diseases,Shandong Province,Jining 272051,P.R. China |
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| Abstract: | Objective To evaluate the efficacy and side-effects of trazodone.Meth ods A double-blind controlled trial was designed for comparing trazodone( M13,F6 ;age 36.2±13.7Ys)with amitriptyline(M11,F8;age 34.6±12.5Ys)to treat depression .5 0mg/d as the initial dose was gradually increased to 150～300mg/d within ten day s for 6 weeks.Their efficacy and side-effects were evaluated by Hamilton Depress i on Scale(HAMD),Hamilton Anxiety Scale(HAMA) and Treatment Emergent Symptoms Scal e(TESS)before and after the treatment.Results There was no signif icant differen ce in recovery ratio and reduction of scores of HAMD and HAMA betwen trazodone a nd amitriptyline group.The common side effects of trazodone was calm.There were much less vegetative nervous system and cardiovascular effects in trazodone than in amit riptyline group.Conclusion Trazodone is a safe and effective anti depressant drug |
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| Keywords: | Trazodone Amitriptyline Depression |
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