缺氧对男性肺心病患者急性发作期下丘脑-垂体-性腺轴功能变化的影响

本文应用放免法检测了50例急性发作期男性肺心病患者及26名正常健康男性之血浆睾酮(T)、雌二醇(E_2)、血清黄体生成激素(LH)、卵泡刺激素(FSH)水平及对黄体生成激素释放激素(LRH)刺激的反应性。结果表明,急性发作期血浆T值明显降低(P<0.01),E_2/T比值显著升高(P<0.01);缓解期二者均恢复至对照水平。急性发作期患者对LRH刺激之反应亦有所减退。血浆E_2、血清LH和FSH水平均无明显变化。患者血浆T值与PaO_2呈明显正相关,E_2/T比值与PaO_2,呈明显负相关,T值、E_2/T比值与PaCO_2均无相关关系。作者提出:缺氧是导致男性肺心病患者急性发作期下丘脑-垂体-性腺轴功能改变的重要影响因素。

Effect of hypoxia on hypothalamic-pituitary-gonadal function in male patients with acute attack of chronic cor pulmonale

The concentrations of plasma testosterone (T), estradiol (E_2), and serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in 50 male patients with chronic cor pulmonale (CCP) and in 26 healthy men were detected by radioimmunoassay, and their responses to luteinizing hormone-releasing hormone (LRH) stimulating test were observed. The results showed that (1) during acute attack there was significantly low T value (P<0.01) and a high E_2/T ratio (P<0.01), and in the remission stage they all returned to'control levels; (2) the patients had significantly low increment in serum LH and FSH levels after the injection of LRH as compared with the controls (P<0.05); (3) there was a positive correlation between PaO_2 and plasma T value, a negative correlation between PaO_2 and plasma E_2/T ratio. It is suggested that hypoxia is an important cause leading to abnormalities of hypothalamie-pituitary-gonadal function in male patients with acute attack of CCP.