肌钙蛋白及肌酸激酶同工酶与老年急性心肌梗死范围的相关性

目的：探讨心肌肌钙蛋白I（cTnI）、心肌肌钙蛋白T（cTnT）、肌酸激酶同工酶（CK-MB）的变化和老年心肌梗死（AMI）患者心肌梗死范围的相关性。方法：回顾性分析2012年9月至2013年9月于我院内科住院的80例老年心肌梗死患者的临床资料，分析治疗前和治疗1周后cTnI、cTnT、CK．MB值与心肌梗死范围的相关性。结果：与治疗前比较，治疗后患者cTnI[（4．63±0．21）／μg／L比（0．154±0．03）μg／L]、cTnT[（0．71±0．05）μg／L比（0．17±0．01）μg／L]、CK．MB[（40．21±2．13）U／L比（23．32±2．11）U／L]水平显著下降，心肌梗死面积[（35．25±4．65）mm。比（23．174±3．76）mm。]显著减小（P均〈0．01）；Pearson相关分析显示，cTnI、cTnT及CK—MB与心肌梗死面积均呈显著正相关（r=0．99、0．98、0．95，P均〈0．01）。结论：肌钙蛋白I、心肌肌钙蛋白T、肌酸激酶同工酶与心肌梗死范围关系密切，这三个指标值的结合可作为判断老年心肌梗死患者心肌梗死范围的重要依据。

Correlation among troponin,CK-MB and acute myocardial infarction range in aged patients

Objective： To explore the correlation among cardiac troponin I （cTnI）, cardiac troponin T （cTnT）, creatine kinase isoenzyme （CK-MB） levels and range of myocardial infarction in aged patients with acute myocardial infarction （AMI）. Methods： Clinical data of 80 aged AMI patients hospitalized in our internal medicine department from Sep 2012 to Sep 2013 were retrospectively analyzed. Correlation among levels of cTnI, cTnT, CK-MB and range of myocardial infarction were analyzed before and one week after treatment. Results： Compared with before treatment, there were significant reductions in levels of cTnI [（4.63±0.21） μg/L vs. （0.15±0.03）μg/L], cTnT [- （0.71±0.05） /μg/Lvs. （0.17±0.01） /μg/L], CK-MB [ （40.21±2.13） U/Lvs. （23.32±2.11） U/L] and myo- cardial infarction area [ （35.25±4.65） mm^2 vs. （23.17±3.76） mm^2] after treatment, P〈0.01 all; Pearson correlation analysis indicated that cTnI, cTnT and CK-MB were all positively correlated with myocardial infarction area （r=0.99, 0.98, 0.95, P〈0.01 all）. Conclusion.. Cardiac troponin I, T and creatine kinase isoenzyme are closely related to myocardial infarction range. Combination of these three indexes can be used as important basis for judging myocardial infarction range in patients with myocardial infarction.