Microbubbles improve the ablation efficiency of extracorporeal high intensity focused ultrasound against kidney tissues |
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Authors: | Tinghe Yu Dingrong Hu Chuanshan Xu |
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Institution: | (1) West China Women and Children’s Hospital, Sichuan University, Chengdu, 610041, China;(2) Institute of Ultrasound Engineering in Medicine, Chongqing Medical University, Chongqing, 400016, China;(3) Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing, 400010, China |
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Abstract: | Objective The necrosis rate is low when ablating kidney tissues with extracorporeal high intensity focused ultrasound (HIFU), and this
drawback has been limiting the application of ultrasonic therapy. The aim of the present study was to determine whether microbubbles
increased the ablation efficiency in vivo.
Methods Goat kidneys were exposed to HIFU (control group) or microbubble-assisted HIFU (experimental group). Microbubbles were intravenously
injected before focused ultrasound exposure. The linear scan was employed and tissue ablation was performed in manner of a
clinical regime. The necrosis rate was determined 24 h after HIFU. Pathological examinations were performed to confirm tissue
necrosis and to determine whether there were unaffected tissues within the exposed volume.
Results The necrosis rate was increased in experimental group (4.17 ± 1.33 vs. 9.32 ± 2.27 mm3/s, P = 0.0007). Ablated tissues formed a hemorrhagic volume on gross examinations, and the boundary between treated and untreated
areas was sharp. There was no intact tissue within the exposed volume. Hemorrhage frequently occurred in insonated parenchymas.
Destructed ghost cells just inside the demarcation were full of vacuoles, when introducing microbubbles. In control group,
the volumes of ablated tissues varied drastically between animals despite a same treatment template.
Conclusion Microbubbles increased the ablation efficiency of HIFU against kidney tissues. A preoperative regime might poorly predict
the therapeutic outcome.
T. Yu and D. Hu contributed equally to this paper. |
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Keywords: | Ablation Kidney Microbubble Necrosis rate High intensity focused ultrasound |
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