| 自体外周血造血干细胞移植联合硼替佐米及大剂量美法仑治疗多发性骨髓瘤3例 |
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| 引用本文： | 孙志强,王季石,卢英豪,谢润兰,龙正美.自体外周血造血干细胞移植联合硼替佐米及大剂量美法仑治疗多发性骨髓瘤3例[J].中国组织工程研究与临床康复,2010,14(10). |
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| 作者姓名： | 孙志强 王季石 卢英豪 谢润兰 龙正美 |
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| 作者单位： | 贵阳医学院附属医院血液科,贵州省贵阳市,550004 |
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| 摘 要： | 背景:自体外周血造血干细胞移植联合大剂量化疗能明显提高多发性骨髓瘤患者完全缓解率和生存率,但复发率较高.硼替佐米是26S蛋白酶体抑制剂,对初治多发性骨髓瘤具有显著疗效.目的:评价自体外周血造血干细胞移植联合硼替佐米及大剂量美法仑对多发性骨髓瘤患者的疗效.方法:回顾性分析2006-10/2007-05贵阳医学院附属医院血液科收治的3例多发性骨髓瘤患者,均采用化疗加粒细胞集落刺激因子方案进行自体外周血造血干细胞的动员.于移植前3 d静脉滴注美法仑200mg/m~2作为预处理方案,停药48 h后回输白体外周血造血干细胞.结果与结论:3例患者均获造血重建,细胞移植后30 d骨髓抑制恢复正常,骨痛改善.细胞移植后,第1,2例患者获得完全缓解,第3例患者获得部分缓解.提示自体外周血造血干细胞移植联合硼替佐米及大剂量美法仑是治疗多发性骨髓的有效手段,患者对预处理方案耐受性较好.
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| 关 键 词： | 多发性骨髓瘤 硼替佐米 美法仑 自体 移植 外周血造血干细胞 干细胞 |
Autologous peripheral blood hemopoietic stem cell transplantation in combination with bortezomib and high-dose melphalan for multiple myeloma in 3 cases |
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| Sun Zhi-qiang,Wang Ji-shi,Lu Ying-hao,Xie Run-lan,Long Zheng-mei.Autologous peripheral blood hemopoietic stem cell transplantation in combination with bortezomib and high-dose melphalan for multiple myeloma in 3 cases[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2010,14(10). |
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| Authors: | Sun Zhi-qiang Wang Ji-shi Lu Ying-hao Xie Run-lan Long Zheng-mei |
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| Institution: | Sun Zhi-qiang,Wang Ji-shi,Lu Ying-hao,Xie Run-lan,Long Zheng-mei Department of Hematology,Affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou Province,China |
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| Abstract: | BACKGROUND: Autologous peripheral blood hemopoietic stem cell transplantation (HSCT) in combination with high-dose chemotherapy significantly improves complete remission and survival rate of multiple myeloma patients. However, the relapse rate is high. Bortezomib is 26S proteasomes inhibitor, and effective on the primary treatment of multiple myeloma. OBJECTIVE: To evaluate the curative effect of HSCT in combination with bortezomib and high dose-melphalan for multiple myeloma. METHODS: A retrospective analy... |
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