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| Expression of MDM2 Protein and mRNA in Condyloma Acuminata | |
| 引用本文： | 朱里,涂亚庭,黄长征,刘厚君,冯爱平. Expression of MDM2 Protein and mRNA in Condyloma Acuminata[J]. 华中科技大学学报(医学英德文版), 2004, 24(5): 493-496. DOI: 10.1007/BF02831118 |
| 作者姓名： | 朱里 涂亚庭 黄长征 刘厚君 冯爱平 |
| 作者单位： | DepartmentofDermatology,UnionHospital,TongjiMedicalCollege,HuazhongUniversityofScienceandTechnology,Wuhan430022,China |
| 摘 要： | In order to investigate the role of murine double minute 2 (MDM2) in cell proliferation and carcinogenesis in condyloma acuminatum (CA), immunohistochemistry and in situ hybridization were used to detect the expression of MDM2 protein and mRNA in normal skin and skin lesions of CA of vulva. PCR was also used to detect HPV types. The results showed that in 32 observed CA specimens, the expression of MDM2 protein and mRNA was detected in 18(56.25 %)and 22 (68.75 %)respectively, while the co-expression of MDM2 protein and mRNA was found in 14. PCR results revealed that HPV6/11 and HPV16/18 subtypes were shown in 28(87.5 %)and 4 (12.5 % )respectively out of 32 CA specimens. Out of the 18 positive specimens expressing MDM2 protein, HPV6/11 subtypes were shown in 15 and HPV16/18 subtypes in 3. In 22 positive specimens expressing MDM2 mRNA, HPV6/ll subtypes were shown in 18 and HPV16/18 subtypes in 4. No expression of MDM2 protein and MDM2 mRNA was observed in normal skin. Our study indicated that the overexpression of MDM2 might be involved in malignant proliferation and carcinogenesis of CA. |
| 关 键 词： | MDM2 HPV16／18 RNA CA PCR |
| 收稿时间： | 2003-08-27 |
Expression of MDM2 protein and mRNA in condyloma acuminata |
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| Zhu Li,Tu Yating,Huang Changzheng,Liu Houjun,Feng Aiping. Expression of MDM2 protein and mRNA in condyloma acuminata[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2004, 24(5): 493-496. DOI: 10.1007/BF02831118 | |
| Authors: | Zhu Li Tu Yating Huang Changzheng Liu Houjun Feng Aiping |
| Affiliation: | Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430022, China |
| Abstract: | In order to investigate the role of murine double minute 2 (MDM2) in cell proliferation and carcinogenesis in condyloma acuminatum (CA), immunohistochemistry and in situ hybridization were used to detect the expression of MDM2 protein and mRNA in normal skin and skin lesions of CA of vulva. PCR was also used to detect HPV types. The results showed that in 32 observed CA specimens, the expression of MDM2 protein and mRNA was detected in 18(56.25 %)and 22(68.75 %)respectively, while the co-expression of MDM2 protein and mRNA was found in 14. PCR results revealed that HPV6/11 and HPV16/18 subtypes were shown in 28(87.5 %)and 4 (12.5 %)respectively out of 32 CA specimens. Out of the 18 positive specimens expressing MDM2 protein, HPV6/11 subtypes were shown in 15 and HPV16/18 subtypes in 3. In 22 positive specimens expressing MDM2 mRNA, HPV6/11 subtypes were shown in 18 and HPV16/18 subtypes in 4. No expression of MDM2 protein and MDM2 mRNA was observed in normal skin. Our study indicated that the overexpression of MDM2 might be involved in malignant proliferation and carcinogenesis of CA. |
| Keywords: | MDM2 oncogene condyloma acuminatum |
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