| 甲康Ⅰ号口服液药效学及临床疗效观察 |
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| 引用本文： | 郑谊,蔡万春,江立富,翟嘉涛,么威,马亚萍. 甲康Ⅰ号口服液药效学及临床疗效观察[J]. 中国药房, 2002, 13(3): 148-149 |
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| 作者姓名： | 郑谊 蔡万春 江立富 翟嘉涛 么威 马亚萍 |
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| 作者单位： | 解放军第五医院,银川市,750004 |
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| 基金项目： | 兰州军区科研项目 (LXH2000-20) |
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| 摘 要： | 目的 :对甲康Ⅰ号口服液药效学及临床疗效进行研究。方法 :采用甲状腺机能亢进动物模型 ,用甲巯基咪唑、生理盐水与甲康Ⅰ号作药效学对比观察 ;采用双肓法治疗205例甲亢患者。结果 :甲康Ⅰ号具有明显降低大鼠T3、T4 和升高TSH作用 ;临床治疗甲亢患者亦有降低T3、T4 和升高TSH作用 ,与对照组比较 ,P<0 05 ,能明显改善临床症状 ,且未发现明显不良反应。结论 :本文所建甲亢动物模型适用于甲康Ⅰ号药效学观察 ;甲康Ⅰ号对甲亢患者有较好的临床疗效
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| 关 键 词： | 甲康Ⅰ号口服液 药效学 临床疗效 |
| 文章编号： | 1001-0408(2002)03-0148-02 |
| 修稿时间： | 2001-06-11 |
Pharmacodynamics and Clinical Therapeutic Effect of Jiakang Ⅰ Oral Liquid |
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| ZHENG Yi,CAI Wanchun,JIANG Lifu,ZHAI Jiatao,YAO Wei,MA Yaping. Pharmacodynamics and Clinical Therapeutic Effect of Jiakang Ⅰ Oral Liquid[J]. China Pharmacy, 2002, 13(3): 148-149 |
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| Authors: | ZHENG Yi CAI Wanchun JIANG Lifu ZHAI Jiatao YAO Wei MA Yaping |
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| Abstract: | OBJECTIVE:To evaluate the pharmacodynamics and therapeutic effect of Jiakang Ⅰ oral liquid.METHODS:The drug actions of tapazole,NS and Jiakang Ⅰ were compared in the animal model of hyperthyroidism.205 hyperthyroidism cases were treated with Jiakang Ⅰ in a double blind design and the therapeutic effect was observed.RESULTS:Pharmacodynamic observation revealed that Jiakang Ⅰ could decreased T3,T4 and increase TSH significantly in rats.Compared with control group treated with tapazole or NS,in Jiakang Ⅰ group,T3 and T4 were obviously reduced and TSH was increased and the clinical symptoms were alleviated without any marked adverse reaction.CONCLUSION:The hyperthyroidism animal model can be applied to evaluating the pharmacodynamic effect of Jiakang Ⅰ.This drug has satisfactory therapeutic effect on hyperthyroidism. |
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| Keywords: | Jiakang I oral liquid pharmacodynamics clinical therapeutic effect |
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