Acute and sub-chronic toxicity studies of the extract of Thunberg Fritillary Bulb |
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| Affiliation: | 1. Department of Pharmacology of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China;2. Department of Biomedicine Science, College of Medicine, University of Toledo, Toledo 43614, United States;3. Drug Safety Evaluation Center, China Institute for Radiation Protection, Taiyuan 030006, China;4. Department of Oncology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China;1. Department of Chemistry, SRMV College of Arts and Science, Coimbatore 641020, TN, India;2. Centre for Crystal Growth, SSN College of Engineering, Kalavakkam 603110, TN, India;3. X-ray Crystallography Laboratory, Post-Graduate Department of Physics, University of Jammu, Jammu Tawi 180006, India;4. Department of Physics, Government Arts College for Women (Autonomous), Pudukottai 622001, TN, India;5. Department of Physics, Cauvery College For Women, Trichy 600018, TN, India;1. Department of Environmental Engineering, National Cheng Kung University, 1, University Road, Tainan City 70101, Taiwan;2. Graduate School of Science and Radiation Research Center, Osaka Prefecture University, 1-2 Gakuen-cho, Sakai, Osaka 599-8570, Japan;1. Imperial College London, UK;2. The Royal Marsden NHS Foundation Trust, London, UK;3. King''s College London, UK;1. Department of Physiology, Shanxi Medical University, Taiyuan 030001, China;2. Department of Neurobiology, Southern Medical University, Guangzhou 510515, China;1. Department of Dermatology, Park Nicollet Health Services, Minneapolis, Minnesota;2. Department of Dermatology, University of Minnesota, Minneapolis, Minnesota;3. Department of Dermatology, Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota;4. University of Minnesota Medical School, Minneapolis, Minnesota;5. Department of Dermatology, Duke University, Durham, North Carolina;6. Division of Dermatology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada;7. Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Washington, DC;8. Department of Dermatology, Columbia University Irving Medical Center, New York, New York;9. Division of Dermatology, University of Louisville, Louisville, Kentucky;10. Associates in Dermatology, Fort Myers, Florida;11. Department of Dermatology, Keck School of Medicine of University of Southern California, Los Angeles, California;12. Department of Dermatology, University of California, San Francisco, San Francisco, California;13. Department of Dermatology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire;14. Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin;15. Department of Dermatology, Cleveland Clinic, Cleveland, Ohio;p. Division of Dermatology, Montreal General Hospital, McGill University, Montreal, Quebec, Canada;q. Division of Dermatology, University of Ottawa, Ottawa, Ontario, Canada |
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| Abstract: | ![]()
The aim of this study was to investigate the acute and sub-chronic toxicity of extract of Thunberg Fritillary Bulb. For the acute toxicity tests, graded doses of the extract were administered orally to mice. The animals were observed for toxic symptoms and mortality daily for 14 days. In the sub-chronic toxicity study, rats were orally administered the extract at doses of 1 and 3 mg/kg body weight (BW) for 26 weeks. After 26 weeks, the rats were sacrificed for hematological, biochemical and histological examination. In the acute toxicity tests, the estimated median lethal dosage (LD50) was 52.2 mg/kg body weight in the mice. In the sub-chronic toxicity tests, a dose of 1 mg/kg body weight presented no toxicity. Above the 1 mg/kg dose, the main adverse signs observed in male rats were body or head tremor and spontaneous motor activity reduction. There were no other significant changes observed in hematology, blood biochemistry, organ weight and organ histology. The overall findings of this study indicate that the extract of Thunberg Fritillary Bulb is non-toxic up to 1 mg/kg body weight, which can be considered a safe application dose. |
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| Keywords: | Acute toxicity Sub-chronic toxicity |
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