Drug allergy in tertiary care in Turkey: Results of a national survey. The ADAPT study: Adult drug allergy perception in Turkey |
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| Affiliation: | 1. Ankara University School of Medicine, Cebeci Research Hospital, Department of Chest Diseases, Division of Immunology and Allergy, Turkey;2. Hacettepe University School of Medicine, Department of Chest Disease, Adult Allergy Unit, Turkey;3. Istanbul University School of Medicine, Department of Internal Medicine, Division of Allergy, Turkey;4. Cumhuriyet University School of Medicine, Department of Chest Diseases, Division of Immunology and Allergic Diseases, Turkey;5. Ege University School of Medicine, Department of Internal Medicine, Division of Allergy and Clinical Immunology, Turkey;6. Ataturk Chest Diseases and Thoracic Surgery, Training and Research Hospital, Turkey;7. Gaziosmanpasa University, School of Medicine, Department of Pulmonary Diseases, Turkey;8. Celal Bayar University School of Medicine, Department of Internal medicine, Division of Immunology and Allergy, Turkey;9. Fatih University School of Medicine, Department of Chest Diseases, Division of Immunology and Allergy, Turkey;10. Izmir Ataturk Training and Research Hospital, Turkey;11. Kırıkkale University School of Medicine, Department of Chest Diseases, Division of Immunology and Allergic Diseases, Turkey;1. Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Universitat de Barcelona, Spain;2. Department of Pediatrics, Hospital Sant Joan de Déu, Universitat de Barcelona, Spain;3. Hematology Department, Hospital Sant Joan de Déu, Universitat de Barcelona, Spain;4. Pharmacy Department, Hospital Sant Joan de Déu, Universitat de Barcelona, Spain;1. IRCCS-A.O.U. San Martino, Genoa, Italy;2. Allergy/Pulmonary Rehabilitation, ICP, Milan, Italy;3. Scientific Department, Stallergenes, Milan, Italy;4. Allergologia e Immunologia Clinica, A.O.U. G. Martino, Messina, Italy;1. Division of Science and Research, Kunming Medical University, Kunming, Yunnan, China;2. Center of Functional Experiment, Kunming Medical University, Kunming, Yunnan, China;3. Department of Physiology, Kunming Medical University, Kunming, Yunnan, China;1. Gulhane Military Medical Academy and Medical School, Department of Internal Medicine, Division of Immunology and Allergic Diseases, Ankara, Turkey;2. Gulhane Military Medical Academy and Medical School, Department of Pulmonary Medicine, Ankara, Turkey;3. Gulhane Military Medical Academy and Medical School, Department of Internal Medicine, Division of Gastroenterology, Ankara, Turkey |
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| Abstract: | ![]()
BackgroundNo data are available on the incidence of drug hypersensitivity (DH) reactions in outpatient settings of tertiary allergy/immunology clinics. Our aims were to document the frequency of outpatient hospital admissions due to DH reactions to allergy/immunology clinics in adults and the management of these reactions in real life. We also investigated whether drug allergy affected social and medical behaviours of the patients.MethodsThis multi-centre study was performed for one year with the participation of 11 out of 16 tertiary allergy/clinical immunology clinics in Turkey. The study group consisted of the patients with DH reactions. Results of a questionnaire including drug reactions and management were recorded.ResultsAmong 54,863 patients, 1000 patients with DH were enrolled with a median of 2.1% of all admissions. In real life conditions, the majority of approaches were performed for finding safe alternatives (65.5%; 1102 out of 1683) with 11.7% positivity. Diagnostic procedures were positive in 27% (154/581) of the patients. The majority of the patients had higher VAS scores for anxiety. A total of 250 subjects (25%) reported that they delayed some medical procedures because of DH.ConclusionOur results documented the frequency of admissions due to DH reactions to allergy/clinical immunology clinics for the first time. Although physicians mostly preferred to perform drug tests in order to find safe alternatives, considering the fact that DH was confirmed in 27% of the patients, use of diagnostic tests should be encouraged, if no contraindication exists in order to avoid mislabelling patients as DH. |
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| Keywords: | Drug allergy Drug hypersensitivity Drug provocation tests Skin prick tests Guidelines Epidemiology |
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