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| 乳香没药对大鼠肝脏毒性的比较研究 | |
| 引用本文： | 周昆,谈英,柳占彪,张跃飞,胡利民,高秀梅. 乳香没药对大鼠肝脏毒性的比较研究[J]. 中国实验方剂学杂志, 2010, 16(6): 221-223 |
| 作者姓名： | 周昆 谈英 柳占彪 张跃飞 胡利民 高秀梅 |
| 作者单位： | 1. 天津中医药大学中医药研究院,天津市中药药理重点实验室,天津,300193 2. 三九医药股份有限公司研发事业部,广东,深圳,518029 |
| 摘 要： | 目的: 比较乳香和没药对大鼠的肝脏毒性。 方法: 48只Wistar大鼠随机分为4组,分别为对照组、乳香没药(1 ∶1)组、乳香组、没药组,各给药组剂量均为2.1 g·kg-1,连续ig 12周。禁食12 h后水合氯醛麻醉动物,取血检测血清生化指标,并解剖称取肝脏湿重计算肝脏系数,并测定肝组织中MDA含量,光镜下对肝脏进行病理组织学检查。 结果: 乳香没药组和乳香组大鼠的血清总胆固醇(TC)和肝组织中丙二醛(MDA)明显高于对照组(P<0.05)。给药组大鼠肝系数均明显升高(P<0.01),肝系数乳香组>乳香没药组>没药组。肝脏病理组织学检查表明,乳香组2只大鼠肝脏中度脂肪变性,而乳香没药组和没药组则未见明显异常。 结论: 乳香对大鼠的肝脏毒性强于没药。 |
| 关 键 词： | 乳香 没药 肝毒性 |
| 收稿时间： | 2010-03-02 |
Comparative Study on Hepatotoxicity of Olibanum and Myrrha in Rats |
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| ZHOU Kun,TAN Ying,LIU Zhan-biao,ZHANG Yue-fei,HU Li-min and GAO Xiu-mei. Comparative Study on Hepatotoxicity of Olibanum and Myrrha in Rats[J]. China Journal of Experimental Traditional Medical Formulae, 2010, 16(6): 221-223 | |
| Authors: | ZHOU Kun TAN Ying LIU Zhan-biao ZHANG Yue-fei HU Li-min GAO Xiu-mei |
| Affiliation: | Institute of Traditional Chinese Medicine, Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin University of Traditional Chinese Medicine, Tianjin 300193,China;R&D Department of Sanjiu Medical & Pharmacutical CO. LTD., Shenzhen 518029,China;Institute of Traditional Chinese Medicine, Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin University of Traditional Chinese Medicine, Tianjin 300193,China;R&D Department of Sanjiu Medical & Pharmacutical CO. LTD., Shenzhen 518029,China;Institute of Traditional Chinese Medicine, Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin University of Traditional Chinese Medicine, Tianjin 300193,China;Institute of Traditional Chinese Medicine, Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin University of Traditional Chinese Medicine, Tianjin 300193,China |
| Abstract: | |
| Keywords: | Olibanum Myrrha hepatotoxicity |
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