DNA修复基因XPCC3多态性与子宫内膜异位症发病相关性分析

目的研究DNA修复基因XRCC3多态性与子宫内膜异位症发病风险的关系。方法采用病例-对照研究的方法,应用PCR-RELP方法检测子宫内膜异位症患者与非子宫内膜异位症妇女XRCC3基因Thr241Met的多态性分布,并分析其多态性与子宫内膜异位症疾病病理过程的关系。结果XRCC3基因多态性在内异症组与对照组存在显著差异(P<0.05),Thr/Met基因表达在内异症组显著增强(P<0.05);Thr241Met基因多态性与内异症病理分期无相关性。结论具有XRCC3 Thr/Met基因型或Met等位基因的个体对内异症的发生有易感性,但与内异症的临床病理分期无关。

Research of the relationship between polymorphisms of DNA repair gene XRCC3 and endometriosis

Objective To investigate the association of the polymorphisms in DNA repair gene XRCC3 with endometriosis risk.Methods The polymorphisms of DNA repair gene XRCC3 between endometriosis patients and controls were detected and whether XRCC3 were associated with the severity of endometriosis or not was evaluated.Genotypes of XRCC3 were analyzed by PCR-RELP.Results There was significantly difference between endometriosis and control groups of XRCC3 genetic polymorphism(P<0.05).The expression of Thr/Met gene was significantly enhanced in endometriosis(P<0.05).There was not association between the distributions of genotypes or alleles of XRCC3 and the stage of endometriosis.Conclusion Patients with XRCC3 Thr/Met or Met allele genotype have susceptibility to endometriosis,but the genotype is not associated with the stage of endomtriosis.