| 2,4-二氨基-5-甲基-6-(N-甲基取代苄氨基)喹唑啉的合成及其抗肿瘤和抗菌作用 |
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| 引用本文： | 蒙小英,张秀平,陈秀华,余爱珍. 2,4-二氨基-5-甲基-6-(N-甲基取代苄氨基)喹唑啉的合成及其抗肿瘤和抗菌作用[J]. 药学学报, 1991, 26(5): 383-386 |
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| 作者姓名： | 蒙小英 张秀平 陈秀华 余爱珍 |
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| 作者单位： | 上海医药工业研究院,上海200433 |
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| 摘 要： | ![]()
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| 关 键 词： | 氨基喹唑啉 抗肿瘤活性 抗菌活性 |
| 收稿时间： | 1990-04-26 |
SYNTHESIS AND ANTIBACTERIAL AS WELL AS ANTINEO-PLASTIC ACTIVITIES OF 2,4-DIAMINO-5-METHYL-6-(N -METHYL-SUBSTITUTED BENZYL)AMINOQUINA-ZOLINES |
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| XY Meng,XP Zhang,XH Chen and AZ Yu. SYNTHESIS AND ANTIBACTERIAL AS WELL AS ANTINEO-PLASTIC ACTIVITIES OF 2,4-DIAMINO-5-METHYL-6-(N -METHYL-SUBSTITUTED BENZYL)AMINOQUINA-ZOLINES[J]. Acta pharmaceutica Sinica, 1991, 26(5): 383-386 |
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| Authors: | XY Meng XP Zhang XH Chen AZ Yu |
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| Affiliation: | Shanghai Institute of Pharmaceutical Industry. |
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| Abstract: | ![]()
This paper reports four methods for the synthesis of 2,4-diamino-5-methyl-6-(N-methyl-substituted benzyl) aminoquinazolines. Six compounds were synthesized and all these compounds showed good anticancer and antibacterial activities. Among them, I5 showed the strongest inhibition against L1210 Leukemia cell and further research has to be done. |
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| Keywords: | Antineoplastic activity Antibacterial activity Aminoquinazoline |
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