难治性结核性胸腔积液中异烟肼浓度的检测和对比

目的检测难治性包裹性结核性胸腔积液中异烟肼的药物浓度。方法对口服异烟肼、异烟肼直接注入包裹性胸腔积液中,检测胸腔积液和血液中异烟肼的浓度。结果口服异烟肼后包裹性胸腔积液中异烟肼的浓度(0.29±0.34)远低于血液中异烟肼的浓度(3.04±1.75);异烟肼直接注入包裹性胸腔积液中异烟肼的浓度(1.62±0.95)远高于血液中异烟肼的浓度(0.25±0.17),以后随注药次数增加,胸腔积液内异烟肼浓度越来越高(3.97±0.94,8.11±2.4),血液中异烟肼浓度无显著增加(0.21±0.26,0.32±0.14)。结论异烟肼直接注入包裹性胸腔积液能明显提高胸腔积液内的药物浓度,是治疗难治性结核性胸腔积液的有效手段。

Refractory tuberculous pleural effusion of concentration of isoniazid in detection and contrast

Objective Detection of refractory encapsulated tuberculous pleura1 effusion in isoniazid drug concentration. Methods On oral isoniazid, isoniazid injected directly into the parcel pleural effusion, detection of pleural effusion and blood isoniazid. Results Oral isoniazid after encapsulated pleural effusion in isoniazid （0. 29 ± 0. 34 ） is far lower than the blood isoniazid （ 3.04 ± 1.75 ） ; Isoniazid injec- ted directly into the encapsulated pleural effusion in isoniazid （ 1.62 ±0. 95 ） than in blood isoniazid （0. 25± 0. 17 ）, Subsequent to the in- jection times increasing, pleura] effusion endometriosis smoke hydrazine concentration becomes higher （3.97 ± 0.94,8. 11± 2.4 ） , no sig- nificant increase in blood concentration of isoniazid （0. 21 ± 0.26,0. 32 ± 0. 14）. Conclusions Isoniazid injected directly into the parcel pleural effusion can obviously improve the drug concentrations in pleural effusion, is refractory to treatment of tuberculous pleural effusion by effective means.