| 两种艾司西酞普兰治疗抑郁症的疗效及安全性 |
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| 引用本文： | 范征莉,杨辉,周小燕. 两种艾司西酞普兰治疗抑郁症的疗效及安全性[J]. 重庆医学, 2011, 40(15): 1492-1493. DOI: 10.3969/j.issn.1671-8348.2011.15.014 |
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| 作者姓名： | 范征莉 杨辉 周小燕 |
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| 作者单位： | 重庆市精神卫生中心心理科,401147;重庆市精神卫生中心心理科,401147;重庆市精神卫生中心心理科,401147 |
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| 摘 要： | 目的比较国产艾司西酞普兰(百洛特)与进口艾司西酞普兰(来士普)治疗抑郁症的疗效及安全性。方法对75例抑郁症患者随机分为百洛特组或来士普组治疗,观察疗程为6周。于入组时和治疗后第2、4、6周,采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)进行疗效评估,用不良反应症状量表(TESS)、血生化、心电图检查进行安全性评估。结果百洛特组有效率为84.6%,来士普组为85.1%,差异无统计学意义(P>0.05)。两组在治疗前和治疗第2、4、6周末各时点HAMD、HAMA评分均明显下降(P<0.01),而两组各时点HAMD、HAMA评分,不良反应发生率组间比较差异均无统计学意义(P>0.05)。结论百洛特与来士普治疗抑郁症的疗效相当,安全性均较好。
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| 关 键 词： | 抑郁症 治疗效果 艾司西酞普兰 安全性 |
Efficacy and safety of two kinds of escitalopram in treating major depressive disorder |
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| Fan Zhengli,Yang Hui,Zhou Xiaoyan. Efficacy and safety of two kinds of escitalopram in treating major depressive disorder[J]. Chongqing Medical Journal, 2011, 40(15): 1492-1493. DOI: 10.3969/j.issn.1671-8348.2011.15.014 |
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| Authors: | Fan Zhengli Yang Hui Zhou Xiaoyan |
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| Affiliation: | Fan Zhengli,Yang Hui,Zhou Xiaoyan(Department of Psychology,Chongqing Mental Health Center,Chongqing 401147,China) |
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| Abstract: | Objective To compare the clinical efficacy and safety of domestic escitalopram and imported escitalopram in the treatment of major depression.Methods 75 cases of major depression were randomly divided into the domestic escitalopram group and imported escilalopram(Lexapro) group with the oaservation treatment course of 6 weeks.The curative efficacy was evaluated by Hamilton Rating Scale for depression and anxiety(HAMD and HAMA) in grouping and 2,4,6 weeks after treatment.The Treat ment Emergent symptom Scale... |
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| Keywords: | depressive disorder treatment outcome escitalopram safet |
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