喹硫平对精神分裂症阴阳性症状和社会功能康复的影响

目的探讨喹硫平对精神分裂症患者阴、阳性症状和社会功能康复的影响。方法将100例精神分裂症患者随机分为两组，每组50例，研究组口服喹硫平治疗，对照组口服舒必利治疗，观察8周。于治疗前及治疗第1周、4周、8周末、出院1月末采用简明精神病量表、阴性症状量表、阳性症状量表评定精神症状，于治疗前和出院1月末采用社会功能缺陷筛选量表评定社会功能缺陷状况。结果治疗后两组简明精神病量表、阴性症状量表、阳性症状量表评分均较治疗前有显著下降（P〈0．01）；治疗第1周末，研究组各量表评分均较对照组下降显著（P〈0．05或0．01），其他时段评分两组均无显著性差异（P均〉0．05）。两组出院1月末社会功能缺陷筛选量表总分及各因子分均较治疗前有显著下降；研究组总分及职业功能、社会活动、家庭活动、生活能力因子分均较对照组下降更显著（P〈0．05或0．01）。结论喹硫平治疗精神分裂症疗效显著且与舒必利相当，但喹硫平起效更快，对社会功能缺陷的改善显著优于舒必利。

Effects of quetiapine on the negative and positive symptoms and social function rehabilitation of schizophrenia

Objective To explore the effects of quetiapine on the negative and positive symptoms and social function rehabilitation of schizophrenia. Methods One hundred schizophrenics were randomly divided into two groups of 50 patients each, research group took oraly quetiapine and control group did sulpiride for 8 weeks. Mental symptoms were assessed with the Brief Psychiatric Rating Scale （BPRS）, the Scale for Assessment of Negative Symptoms （SANS） and the Scale for Assessment of Positive Symptoms （SAPS） before treatment and at the end of the 1st , 4th , 8th week as well as the 1st month after discharge, and social disability with the Social Disability Screening Schedule（SDSS） before discharge and at the end of the 1st month after discharge. Results After treatment, scores of the BPRS, SANS and SAPS of both groups lowered more significantly compared with pretreatment（P〈0.01） ; at the end of the 1st week, scores of all sacles lowered more significantly in the research than in the control group（P〈0.05 or 0.01）, and there were no significant differences between the 2 groups in the other periods（all P〉0.05）. At the end of the ist month after discharge, the total and each factor scores of the SDSS of both groups lowered more significantly compared with pretreatment; the total and occupation function, social activities, family activities, viability score lowered more significantly in the research than in the control group（P〈0.05 or 0.01） . Conclussion Quetiapine is as significantly effective as sulpiride in the treatment of schizophrenia, but the former takes effect more rapidly and improves social disability more significantly.