| IDO和CD4^＋CD25^＋调节性T细胞在肿瘤免疫逃逸中相互作用的研究进展 |
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| 引用本文： | 王慧,潘科,夏建川. IDO和CD4^＋CD25^＋调节性T细胞在肿瘤免疫逃逸中相互作用的研究进展[J]. 癌症, 2009, 28(2): 221-225 |
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| 作者姓名： | 王慧 潘科 夏建川 |
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| 作者单位： | 华南肿瘤学国家重点实验室,广东广州,510060;中山大学肿瘤防治中心实验研究部,广东广州,510060 |
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| 摘 要： | 肿瘤可以通过多种方式逃逸机体免疫系统的监控。吲哚胺-2，3双加氧酶（indoleamine．2，3-dioxygenase，IDO）和CD4^＋CD25^＋调节性T细胞（CD4^＋CD25^＋ regulatory Tcells，Tregs）是近些年在肿瘤免疫逃逸领域中备受关注的两个重要因素。两者相互作用在肿瘤免疫逃逸机制中起着尤为关键的作用，已引起众多研究者的关注。本文就IDO及Tregs在肿瘤免疫逃逸中的作用以及两者之间的相互关系等方面的研究进展作一综述。
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| 关 键 词： | 吲哚胺-2,3双加氧酶 T细胞 肿瘤 免疫逃逸 |
Interaction of Indoleamine-2,3-Dioxyagnase and CD4+CD25+Regulatory T Cells in Tumor Immune Escape |
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| Hui Wang,Ke Pan,Jian-Chuan Xia. Interaction of Indoleamine-2,3-Dioxyagnase and CD4+CD25+Regulatory T Cells in Tumor Immune Escape[J]. Chinese journal of cancer, 2009, 28(2): 221-225 |
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| Authors: | Hui Wang Ke Pan Jian-Chuan Xia |
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| Affiliation: | Hui Wang, Ke Pan, and Jian-Chuan Xia (1. State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P. R. China 2. Research Department, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P. R. China) |
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| Abstract: | There are numerous factors involved in the tumor escape from immune surveillance. Recently, considerable attention has been given to indoleamine 2,3-dioxygenase （IDO） and Tregs （CD4^＋CD25^＋regulatory T cells）. The interaction between the two may play a crucial role in tumor immune escape. This article reviewed the correlation between IDO and Tregs in tumor immune escape. |
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| Keywords: | indoleamine-2 3-dioxygenase CD4^＋CD25^＋ regulatory T cells tumor immune escape |
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