2008年某院细菌耐药性监测分析

目的了解成都市第七人民医院2008年感染患者中分离细菌的耐药情况。方法采用微量肉汤稀释法和美国临床和实验室标准协会(CLSI)2007年的判断标准对1122株临床分离株作药敏试验。结果耐甲氧西林金黄色葡萄球菌(MRSA)和耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)的检出率分别为48.6%和83.5%。绝大多数葡萄球菌对奎奴普丁/达福普丁敏感,未发现对万古霉素和利奈唑胺耐药的菌株。未发现对万古霉素耐药的肠球菌。大肠埃希菌、肺炎克雷伯菌和产酸克雷伯菌ESBLs的检出率分别为40.9%、37.6%和31.6%。铜绿假单胞菌对亚胺培南的耐药率为5.0%,而鲍曼不动杆菌对亚胺培南敏感。结论细菌耐药性问题是抗感染治疗的主要威胁,合理使用抗菌药物以降低耐药性同时采取有效措施控制耐药性的传播非常重要。

Surveillance of Antimicrobial Resistance in A Hospital in 2008

Objective To investigate the antimicrobial resistance of clinical isolates in seventh people' s Hospital of Chengdu during 2008. Methods Minimal inhibitory concentrations test (broth microdilution method)was used to study the antimicrobial resistance. Results The prevalence of methicillin-resistant Staphylococcus aureus (MRSA)and methicillin-resistant coagulase-negative Staphylococci (MRCNS)was 48.6% and 83.5%,respectively. Most of isolates of Staphylococcus were susceptible to synercid. All isolates were s...