谷胱甘肽S-转移酶与膀胱癌关系的研究

目的：探讨谷胱甘肽S－转移酶（GST）与膀胱癌的关系。方法：检测58例膀胱癌患者（膀胱癌组）、80例泌尿系非肿瘤患者（泌尿系非肿瘤组）和40例正常对照者（正常对照组）血清中GST活性及24例膀胱癌患者癌组织、配对癌周正常组织和13例正常膀胱组织中GST活性。结果：膀胱癌组织血清中GST活性明显高于泌尿系非肿瘤组和正常对照组（P＜0．01）,泌尿系非肿瘤组与正常对照组之间GST活性差异无显著性意义（P＞0．05）,膀胱癌组癌组织中GST活性明显高于癌周正常组织及正常膀胱组织（P＜0．01）,癌周正常组织与正常膀胱组织之间,GST活性差异无显著性意义（P＞0．05）。各级和各期膀胱癌之间血清中 GST活性及各级膀胱癌组织之间GST活性差异均无显著性意义（P＞0．05）,而Ⅱ-Ⅳ期膀膛癌周期组织中GST活性较I期增高（P＜0．05）。结论：膀胱癌患者GST活性明显增高,GST活性在癌组织中随着癌分期的增高而增加,提示GST与膀胱癌的发生及发展有关。

The study of the glitathione S transferase activity in blader cancer

Purpose:To study the relationship between the glitathione S transferase and bladder cancer. Methods: The glutathione Stransferase GST) activity has been studied in serum of 58 bladder cancer patients,80 urinary non-tumor patients and 40 normal controls as well as in 27 cancer tissues,adjacent normal tissues and 13 normal bladder tissues.The grade and stage are classified according to the pathology. Results:The GST activity in serum of bladder cancer patients is much higher than that of non-tumor patients and normal control (P<0.001=. There is no difference of GST activity between non-tumor patients and normal controls. The GST activity in cancer tissues is significantly increased as compared with adjacent mormal tissues and normal controls (P<0.001=.There is no difference of GST activity between adjacent normal tissues and normal tissues. Among groups of different grade, the GST activity had no statistically differences either in serum or in cancer tissues.But the enzyme activity is increased in high stage (P<0.05. Conclusions:The results revealed a positive relation between the GST activity and the development of the bladder cancer as well as the malignant degree.