首页 | 本学科首页   官方微博 | 高级检索  
     


Dopamine transporters, D2 receptors, and glucose metabolism in corticobasal degeneration.
Authors:Stefanie Klaffke  Andrea A Kuhn  Michail Plotkin  Holger Amthauer  Daniel Harnack  Roland Felix  Andreas Kupsch
Affiliation:Department of Neurology, University Medicine Berlin, Berlin, Germany.
Abstract:Alterations in presynaptic and postsynaptic dopaminergic system and cerebral glucose metabolism in corticobasal degeneration (CBD) were assessed to evaluate the potential usefulness of different imaging methods for CBD. (123)I-FP-CIT/(123)I-beta-CIT SPECT and (123)I-IBZM SPECT as well as (18)F-FDG PET were performed in eight CBD patients. Decreased presynaptic dopamine transporter binding was found in all CBD patients while D2 receptor binding was reduced in only one patient. (18)F-FDG PET displayed a contralateral hypometabolism in cortical and subcortical areas in seven out of eight patients. Our results demonstrate that glucose metabolism and DAT are reduced, while D2 receptors may be frequently preserved in CBD.
Keywords:SPECT  PET  corticobasal degeneration  atypical parkinsonian syndromes
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号