Strong expression of CD133 is associated with increased cholangiocarcinoma progression |
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| Authors: | Leelawat Kawin Thongtawee Taweesak Narong Siriluck Subwongcharoen Somboon Treepongkaruna Sa-ad |
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| Affiliation: | Kawin Leelawat,Taweesak Thongtawee,Siriluck Narong,Somboon Subwongcharoen,Sa-ad Treepongkaruna,Department of Surgery,Rajavithi Hospital,Bangkok,10400,Thailand College of Medicine,Rangsit University,Thailand |
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| Abstract: | ![]()
AIM:To determine the role of CD133 in cholangiocarcinoma progression. METHODS:CD133 protein expression was evaluated by immunohistochemistry in 34 cholangiocarcinoma specimens.In addition,proliferation,chemoresistance and invasive properties of CD133-enriched(CD133 + ) and CD133-depleted(CD133 )RMCCA1 cholangiocarcinoma cells were studied and compared. RESULTS:Strong CD133 expression was observed in 67.6%(23/34)of the cholangiocarcinoma specimens. Strong expression of CD133 was significantly associated with... |
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| Keywords: | CD133 Cholangiocarcinoma Immunohistochemistry Invasion Metastasis |
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