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Transient micro-elastography: A novel non-invasive approach to measure liver stiffness in mice |
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| Authors: | Bastard Cécile Bosisio Matteo R Chabert Michèle Kalopissis Athina D Mahrouf-Yorgov Meriem Gilgenkrantz Hélène Mueller Sebastian Sandrin Laurent |
| Affiliation: | Echosens, Research and Development Department, Paris, France. cecile.bastard@echosens.com |
| Abstract: | AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below ... |
| Keywords: | Transient elastography Micro-elastography Liver stiffness Liver Mice Amyloidosis Fibrosis Ultrasound |
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