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| 白癜风患者LFA-1、ICAM-1的检测及其与移植疗效的相关性研究 | |
| 引用本文： | 胡晶晶,许爱娥,关翠萍,郑冬娣. 白癜风患者LFA-1、ICAM-1的检测及其与移植疗效的相关性研究[J]. 中国中西医结合皮肤性病学杂志, 2011, 10(1) |
| 作者姓名： | 胡晶晶 许爱娥 关翠萍 郑冬娣 |
| 作者单位： | 1. 浙江中医药大学,杭州,310009 2. 浙江中医药大学附属杭州市第三人民医院,杭州,310009 |
| 摘 要： | 目的探讨白癜风自体表皮移植疗效与LFA-1、ICAM-1的相关性。方法对20例稳定期白癜风患者进行负压吸疱移植治疗并收集白斑及非白斑区的疱液,用ELISA方法测定组织液中LFA-1、ICAM-1的水平。移植后1个月观察疗效。结果 20例白癜风患者局部白斑区与非白斑区组织液ICAM-1、LFA-1水平相比,具有统计学差异。14例寻常型白癜风患者局部白斑与非白斑区组织液ICAM-1、LFA-1水平比较具有统计学差异。6例节段型白癜风患者白斑与非白斑区组织液ICAM-1、LFA-1水平比较无统计学差异。移植失败组白斑区ICAM-1的浓度明显高于成功组(P<0.05),非白斑区ICAM-1的浓度比较则无统计学意义。两组之间LFA-1的浓度比较无统计学意义。结论 LFA-1及其配体ICAM-1的异常表达对白癜风患者皮损区的微环境改变有一定的影响,可能与自体表皮移植疗效相关。 |
| 关 键 词： | 白癜风 黑素细胞 淋巴细胞相关抗原-1 细胞间黏附分子-1 移植 |
Relationship Between the Efficacy of Autologous Epidermal Grafting and the Levels of Lymphocyte Function Associated Antigen-1, Intercellular Adhesion Molecule-1 in Vitiligo |
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| HU Jing-jing,XU Ai-e,GUAN Cui-ping,ZHENG Dong-di. Relationship Between the Efficacy of Autologous Epidermal Grafting and the Levels of Lymphocyte Function Associated Antigen-1, Intercellular Adhesion Molecule-1 in Vitiligo[J]. Chinese J of Dermatovenerology Integr Tradit and West Med, 2011, 10(1) | |
| Authors: | HU Jing-jing XU Ai-e GUAN Cui-ping ZHENG Dong-di |
| Affiliation: | HU Jing-jing1,XU Ai-e2,GUAN Cui-ping2,ZHENG Dong-di2 1.Zhejiang Chinese Medical University,Hangzhou 310009,China,2.Third People's Hospital Affiliated to Zhejiang Chinese Medical University |
| Abstract: | Objective To investigate the relationship between the efficacy of autologous epidermal grafting and the levels of lymphocyte function associated antigen(LFA)-1,intercellular adhesion molecule(ICAM)-1 in vitiligo.Methods 20 patients with stable vitiligo receiving autologous epidermal grafting were included in this study.Suction blister fluid was collected from vitiligous lesions and normal skin in these patients.Enzyme-linked immunosorbent assay(ELISA) was used to detect the levels of LFA-1 and ICAM-1 in suc... |
| Keywords: | vitiligo melanocyte lymphocyte functional antigen-1 intercellular adhesion molecule-1 grafting |
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