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Impact of remote ischemic preconditioning on wound healing in small bowel anastomoses |
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| Authors: | Holzner Philipp Anton Kulemann Birte Kuesters Simon Timme Sylvia Hoeppner Jens Hopt Ulrich Theodor Marjanovic Goran |
| Affiliation: | Philipp Anton Holzner,Birte Kulemann,Simon Kuesters,Jens Hoeppner,Ulrich Theodor Hopt,Goran Marjanovic,Surgical Metabolic and Anastomotic Research Team,Department of General and Visceral Surgery,Albert Ludwigs University of Freiburg,Freiburg 79106,Germany Sylvia Timme,Institute of Pathology,Germany |
| Abstract: | AIM: To investigate the influence of remote ischemic preconditioning (RIPC) on anastomotic integrity. METHODS: Sixty male Wistar rats were randomized to six groups. The control group (n = 10) had an end-to-end ileal anastomosis without RIPC. The preconditioned groups (n = 34) varied in time of ischemia and time of reperfusion. One group received the amino acid L-arginine before constructing the anastomosis (n = 9). On postoperative day 4, the rats were re-laparotomized, and bursting pressure, hydroxyproline... |
| Keywords: | Anastomotic healing Hydroxyproline Bursting pressure Mucosal injury index Wound healing Remote ischemic preconditioning |
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