城市体检人群高尿酸血症患病情况及危险因素分析

摘要：目的　了解哈尔滨市体检人群高尿酸血症（ＨＵＡ）的患病情况及其危险因素。方法　采用分层整群
随机抽样方法对哈尔滨市３５５１例参加健康体检的人群进行体格和生化检查。运用ＳＰＳＳ２０．０软件进行狋检
验和χ
２ 检验，运用Ｌｏｇｉｓｔｉｃ回归分析ＨＵＡ 的相关危险因素，犘＜０．０５为差异有统计学意义。结果　所调
查的人群中，男性血尿酸水平为（３６２．６４±８０．４７）μｍｏｌ／Ｌ，女性为（２７１．４９±６６．５５）μｍｏｌ／Ｌ，男性高于
女性（狋＝３６．８９，犘＜０．０５）；男性ＨＵＡ 患病率为２４．２７％，女性为９．６２％，男性高于女性（χ
２＝１３３．３６，
犘＜０．０５），男性中，ＨＵＡ 患病率以１９～２９、３０～３９ 岁年龄组最高，分别为２９．７３％、２９．７４％；多因素
ｌｏｇｉｓｔｉｃ回归分析表明，男性、肥胖、血脂代谢异常和脂肪肝是ＨＵＡ 患病的主要危险因素（ＯＲ＞１，犘＜
０．０５）。结论　本调查研究体检人群男性ＨＵＡ 的患病率较高，且发病呈年轻化趋势；ＨＵＡ 与肥胖、血脂
代谢异常及脂肪肝的关系密切。
关键词：高尿酸血症；患病率；危险因素；相关性
中图分类号：Ｒ５８９．７　　文献标识码：Ｂ　　文章编号：１００９ ６６３９ （２０１４）０４ ０３２８ ０４

Analysis on prevalence and influencing factors of hyperuricemia in urban check-up residents

Objective To understand the prevalence and related risk factors of hyperuricemia（HUA）among urban check-up residents in Harbin. Methods A stratified cluster sampling method was applied to randomly select 3551healthy check-up residents in Harbin.Physical as well as bio-chemical examinations were conducted.T-test and chi-square test were used for data analysis,and Logistic regression analysis was used to analyze risk factors. Results The average serum uric acid value was 362.64±80.47μmol/L for males which was higher than that in females（271.49±66.55μmol/L）（t=36.89,P＆lt;0.05）,The prevalence of hyperuricemia was 24.27%for males,which was also higher compared to that in females（9.62%）（χ2=133.36,P＆lt;0.05）.The prevalence of HUA was found to be the highest of 29.7% in male residents aged 19-39years.Logistic regression analysis revealed that male,obesity,dyslipidemia and fatty liver were the major risk factors（OR＆gt;1,P＆lt;0.05）of hyperuricemia. Conclusions The prevalence of hyperuricemia among urban check-up male residents is high,especially in young adults.Male,obesity,fatty liver and dyslipidemia are all closely associated with hypemricemia.