０１４－２０１７年金华市居民脑血管病死亡情况分析

摘要：目的　分析２０１４－２０１７年金华市居民脑血管病死亡的流行病学特征，为制定脑血管病预防和控制措 施提供科学依据。方法　根据“浙江省慢性病监测信息管理系统” 中２０１４－２０１７ 年金华市９ 个县（市、 区）户籍死亡的监测数据，采用“浙江省死因监测数据审核软件” 分析脑血管病不同性别、城市农村、不 同年龄段及不同类型脑血管病死亡率、标化死亡率、潜在减寿年数（ＰＹＬＬ）、平均减寿年数（ＡＹＬＬ） 和 减寿率（ＰＹＬＬＲ）等。结果　２０１４－２０１７ 年金华市居民脑血管病死亡率为１２１．１４／１０ 万， 标化死亡率 １０８．８９／１０万，死亡率呈高水平稳定态势， 占全死因的１８．７４％， 居全死因第２ 位。其中男性死亡率 １２４．６７／１０万，标化死亡率１１２．８９／１０万，女性死亡率１１７．４６／１０万，标化死亡率１０５．０９／１０万，男性高于 女性，城市死亡率１０５．７８／１０ 万， 标化死亡率１１３．８３／１０ 万， 农村死亡率１２３．４９／１０ 万， 标化死亡率 １０８．３０／１０万，城市高于农村。≥６５岁老年人脑血管病死亡率高达１０００．２８／１０ 万，占全人群的８８．７８％。 脑血管病死亡以脑出血、脑血管后遗症和脑梗死为主，占全部脑血管病死亡的８６．８８％。２０１４－２０１７年脑血 管病潜在减寿７１１８４人年；以期望寿命为基准，脑血管病患者平均每人因脑血管病减寿３．０７岁；按总人口 计算，金华市居民平均每人因脑血管病损失３．７２‰生命年。结论　脑血管病是严重危害金华市居民身体健康 和生活质量的重点疾病，应进一步加强针对脑血管病行为危险因素开展行为干预，提高居民生命质量。 关键词：脑血管病；死亡率；标化死亡率；构成比；潜在减寿年数；平均减寿年数；减寿率 中图分类号：Ｒ１９５　　文献标识码：Ａ　　文章编号：１００９ ６６３９ （２０１９）０３ ０２０８ ０４

8-Hydroxydeoxyguanine level in urine among uranium mining workers

Objective To determine the urinary 8-Hydroxydeoxyguanine（8-OHdG）level among uranium mining workers. Methods A total of 99male uranium miners were randomly enrolled including 55underground miners and 44 millers.Meanwhile,44executive staffs or new employees were randomly selected as controls.The urinary level of 8-OHdG was detected using ELISA kits.Chi-square test,analysis of variance and multiple linear regression were used to analyze the data. Results The urinary levels of 8-OHdG among underground uranium miners,millers and controls were 64.91±60.06ng/mgCr,52.08±23.31ng/mgCr and 51.50 ± 29.36ng/mgCr,respectively.The differences were not statistically significant（F = 1.60, P=0.21）.Even though the level of urinary 8-OHdG in underground miners and millers with 5to 9years of service was higher than that in those with less than 5years and longer than 10years service,there were no significant differences（F=0.65,P=0.53;F=0.85,P=0.44）. Conclusions The urinary level of 8-OHdG in uranium mining workers is not higher than that in control workers,indicating that low-dose-rate whole-body irradiation may induce adaptive response in terms of initial DNA damage.