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Pseudomonas aeruginosa Endophthalmitis: Clinical Outcomes and Antibiotic Susceptibilities |
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| Authors: | Khalil Ghasemi Falavarjani Sayyed Amirpooya Alemzadeh Abbas Habibi Ali Hadavandkhani Sareh Askari Arash Pourhabibi |
| Affiliation: | 1. Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran;2. Doheny Eye Institute, University of California Los Angeles, Los Angeles, California, USA |
| Abstract: | Purpose: To report the clinical characteristics, antibiotic susceptibilities, and visual outcomes for eyes with endophthalmitis caused by Pseudomonas aeruginosa. Methods: In this retrospective, non-comparative case series, medical records of eyes with culture-proven Pseudomonas aeruginosa endophthalmitis, who were treated from April 2005 to April 2015 at a referral center in Tehran were reviewed. Clinical features, antibiotic susceptibilities, and visual outcomes were assessed. Results: In total, 20 eyes of 19 patients were identified. The clinical settings included cataract surgery (85%), pars plana vitrectomy (5%), endogenous source (5%), and intravitreal bevacizumab injection (5%). Presenting visual acuity ranged from 20/120 to no light perception. Pars plana vitrectomy with intravitreal antibiotic injection was performed as the initial treatment in 16 eyes (80%). The organisms were sensitive to ciprofloxacin and imipenem in 100%; amikacin in 88.3%; ceftazidime in 83.4%; and tobramycin in 83.4% of isolates tested. Final visual acuity was hand motions or worse in 18 eyes (90%). Evisceration was performed in five eyes (20%). Conclusions: Susceptibility to ciprofloxacin and imipenem was found in all isolates tested. Despite appropriate treatment, visual and anatomic outcomes were generally poor. |
| Keywords: | Antibiotics endophthalmitis Pseudomonas aeruginosa |