产妇住址邻近石油化工厂与不良妊娠结局关系的病例对照研究

以产妇住址与某石油化工厂距离为暴露指标，以先天畸形、死胎、出生低体重和早产等不良妊娠结局为效应指标，采用病例对照研究方法探讨石油化工企业污染与不良妊娠结局的关系。经多项分类Ｌｏｇｉｓｔｉｃ回归模型分析，结果发现：控制某些混杂因素作用后，距离与发病的显著性联系；且相对危险性随距离的增大而逐渐降低。居住在３ｋｍ以内者发生先天畸形、死胎和出生低体重的危险性增加，而与早产发生无关。提示石油化工企业污染可能是其周围居民发生不良妊娠结局的危险因素之一。

A Case-control Study on Relationship between Adverse Pregnancy Outcomes and presence of Petrochemical Plant in Vicinity of Residence of Pregnant Women

A case-control sindy was carried out to explore the relationship betweed pollution of petrochemical industry and anverse pregnancy outcomes (APOs ) among women living near the plant, in which distance from maternal residence to the plant was taken as exposure indicator and APOs included congenital malformation , stillbirth, lower-birth-weight. and prematury. It was found with polychotomous logistic model that there was a significant association of exposure and APOs under controlling some confounding factors (X2=19. 75, df = 4, P= 0. 0006 );the longer distance, the smaller risk. The mothers whose residence distance was within 3 Km from the plant had higher risk to give birth to a child with congenital malformation or stillbirth or low-birth-weight. hut not prematury delivery. The results suggested that pollution of the plant were one of the risk factors of the mothers suffering from APOs.