| HLA-Cw研究进展 |
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| 引用本文： | 马红京,肖露露,郭坤元.HLA-Cw研究进展[J].中国实验血液学杂志,2004,12(5):699-703. |
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| 作者姓名： | 马红京 肖露露 郭坤元 |
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| 作者单位： | 第一军医大学珠江医院血液科,广州,510282 |
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| 基金项目： | 广州市重大科研项目基金资助项目(编号 :2 0 0 0 -Z -0 2 2 -0 1) |
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| 摘 要： | HLA—Cw属于经典的HLA—Ⅰ类基因，HLA—Cw分子与HLA—A、B分子一样具有高度多态性，广泛分布于有核细胞表面，不仅呈递内源性多肽给CD8^ T细胞，诱发特异性细胞杀伤效应，还可作为NK细胞免疫球蛋白样受体(KIR)的配体参与免疫反应。因此，HLA—Cw与疾病相关性研究、在移植免疫、抗病毒、抗肿瘤免疫中的作用日益受到重视。
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| 关 键 词： | HLA—Cw HLA-1 移植免疫 肿瘤免疫 |
| 文章编号： | 1009-2137(2004)05-0699-05 |
| 修稿时间： | 2003年9月26日 |
Progress on the Study of HLA-Cw-Review |
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| MA Hong-Jing,XIAO Lu-Lu,GUO Kun-Yuan.Progress on the Study of HLA-Cw-Review[J].Journal of Experimental Hematology,2004,12(5):699-703. |
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| Authors: | MA Hong-Jing XIAO Lu-Lu GUO Kun-Yuan |
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| Institution: | Department of Hematology, Zhujiang Hospital, The First Military Medical University, Guangzhou 510282, China. |
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| Abstract: | HLA-Cw belongs to classic HLA-I gene, HLA-Cw molecules have high polymorphism li ke HLA-A and B molecules. They distribute extensively on the surfaces of karyo te, not only presenting endogenetic antigen to CD8 T cells to induce specific ki lling effect, but also participating in immunologic reaction as the ligands of k iller cell immunoglobulin-like receptor (KIR). Thus it has been valued for t heir relations to diseases and the functions in transplantation immunity, anti v irus and anti-tumor immunity. |
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| Keywords: | HLA-Cw HLA-1 transplantation immunity tumor im munity |
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