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| 消炎痛对大鼠肝线粒体呼吸活性和Ca~(2+)摄取的影响 | |
| 引用本文： | 沈杰,张席锦,王志均. 消炎痛对大鼠肝线粒体呼吸活性和Ca~(2+)摄取的影响[J]. 北京大学学报(医学版), 1991, 0(1) |
| 作者姓名： | 沈杰 张席锦 王志均 |
| 作者单位： | 北京医科大学生理学教研室(沈杰，张席锦)，北京医科大学生理学教研室(王志均) |
| 摘 要： | 本文观察了消炎痛对正常和CCl_4损伤大鼠肝线粒体呼吸活性和钙离子摄取的影响。经消炎痛预处理的大鼠,CCl_4损伤后,肝线粒体仍维持较好的呼吸活性和Ca~(2+)的摄取能力。在不加CCl_4损伤的大鼠,经消炎痛预处理,其肝线粒体的呼吸活性也有变化。提示,消炎痛有可能通过改善线粒体的功能,保证能量供应而起保护作用。 |
| 关 键 词： | 消炎病 四氯化碳 线粒体 肝 呼吸活性 钙摄取 |
EFFECTS OF INDOMETHACIN ON THE RESPIRATORY ACTIVITY AND CALCIUM UPTAKE OF LIVER MITOCHONDRIA IN RATS |
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| Shen Jie,et al. EFFECTS OF INDOMETHACIN ON THE RESPIRATORY ACTIVITY AND CALCIUM UPTAKE OF LIVER MITOCHONDRIA IN RATS[J]. Journal of Peking University. Health sciences, 1991, 0(1) | |
| Authors: | Shen Jie et al |
| Affiliation: | Shen Jie,et al Department of Physiology |
| Abstract: | In order to elucidate the mechanism of hepatic protection of indomethacin, we observed the effectsof indomethacin on respiratory activity and calcium uptake of liver mitochondria in normal and CCl_4-injured rats. Carbon tetrachlorde could induce severe injury of mitochondria, the respiration-stimula-ting effects of ADP, CCCP and CaCl_2 were reduced markedly. But in the rats pretreated withindomethacin, the liver metochondria still maintained good respiratory activity and the calcium uptakecapability after CCl_4 injury. In the animals without injury with CCl_4, the respiratory activity in ratspretteated with indomethacin also differed from that in the controls. It is possible that indomethacinprotects liver by improving mitochondrial function, thus maintaining the hepatic energy supply. |
| Keywords: | Indomethacin Carbon tetrachloride Mitochondria liver Respiratory activity Calcium uptake |
| 本文献已被 CNKI 等数据库收录！ | |