慢性肾脏病患者贫血发病情况分析

目的探讨CKD患者贫血的发病情况及其相关因素.方法收集2007年1月至2010年1月在云南省第三人民医院肾脏血液风湿免疫科住院的CKD患者465例,对其临床和实验室资料进行回顾性分析.结果 465例CKD患者中,贫血的发病率为72.04%,其中年龄〈30岁、30～50岁、50～70岁、〉70岁的患者贫血的发病率依次为47.06%、60.94%、74.42%、86.26%;CKDⅠ～Ⅴ期的患者贫血的发病率依次为24.19%、43.84%、63.22%、88.61%和99.39%;经eGFR矫正后,不同肾脏基础疾病患者贫血的发病率由高到低依次为糖尿病肾病（78.78%）、高血压肾病（66.00%）、慢性肾小球肾炎（65.61%）和多囊肾（60.00%）;透析组与非透析组患者贫血的发病率分别为99.00%和51.75%（P〈0.001）.单因素分析表明,年龄、肾功能情况及透析与否均与贫血的发病率相关.结论慢性肾脏病患者贫血的发病率较高,肾功能减退、年龄等是其发生的危险因素.

The Prevalence of Anemia in Patients with Chronic Kidney Disease

Objective To investigate the prevalence of anemia in the patients with chronic kidney disease（CKD）and the related factors.Method The data of 465 in-patients with CKD in our hospital from January 2007 to January 2010 were collected and retrospectively analyzed.Results In the 465 patients with CKD,the prevalence of anemia was 72.04%,the prevalence of anemia in patients 30 years,30～50 years,50～70 years,and70 years was 47.06%,60.94%,74.45% and 86.26%,respectively.The prevalence of anemia in patients with CKD in stageⅠ～Ⅴwas 24.19%,43.84%,63.22%,88.61% and 99.39%,respectively.The prevalence of anemia in patients with CKD corrected by GFR was associated with varied underling diseases,and the sequence from high to low was diabetic nephropathy（78.78%）,hypertensive nephropathy（66.00%）,chronic glomerulonephritis（65.61%）and ploycystic renal disease（60.00%）.The prevalence of anemia in dialysis patients and non-dialysis patients was 97.79% and 53.45%（P〈0.01）.Age,kidney function and dialysis were correlated to anemia significantly by monofactor analysis.Conclusions The prevalence of anemia in patients with chronic kidney diease is high.The kidney function and age are identified as independent risk factors of anemia.