代谢综合征与非酒精性脂肪肝的相关性分析

摘要:目的　通过流行病学调查，分析非酒精性脂肪性肝病（NAFLD）的相关危险因素，以探讨NAFLD与代谢综合征（MS）的相关性。方法　873人依据体检情况分为NAFLD组和非NAFLD组及MS组和非MS组，分析体重指数（BMI）、血压、血脂、血糖（FBG）等因素与NAFLD的相关性。结果　（1）NAFLD患病率41.123%，男性患病率高于女性（χ2＝21.804，P＜0.001）。MS患病率15.693%，MS组NAFLD患病率高于非MS组（χ2＝99.171，P＜0.001）。（2）NAFLD组BMI、FBG、收缩压（SBP）、舒张压（DBP）、甘油三酯（TG）、胆固醇（TC）、低密度脂蛋白（LDL-C）、谷丙转氨酶（ALT）、尿酸（UA）值均高于非NAFLD组（P＜0.001），谷草转氨酶（AST）值高于非NAFLD组（t＝3.242，P＝0.001），HDL-C值低于非NAFLD组（t＝3.510，P＜0.001）；超重和（或）肥胖、高血糖、高血压、高TG、低HDL-C、高尿酸血症、MS阳性率均高于非NAFLD组（P＜0.001），肝功能异常阳性率高于非NAFLD组（t＝10.119，P＝0.002）。（3）NAFLD患病率随着MS诊断标准中诊断项目的增多呈上升趋势（χ2＝239.918，P＜0.001）。结论　MS与NAFLD密切相关，并相互影响。

Correlation analysis of non-alcoholic fatty liver disease with metabolic syndrome

Abstract: Objective To analyze the risk factors of non-alcoholic fatty liver disease (NAFLD) and explore the correlation of NAFLD with metabolic syndrome. Methods 873 people were divided into the NAFLD group and non-NAFLD group, the MS group and non-MS group based on the physical examination outcomes. The relations of NAFLD with factors including BMI, blood pressure, blood-lipid, blood sugar were analyzed. Results (1) The NAFLD sickness rate was 41.123%, males had higher sickness rate than females (χ2=21.804, P<0.001). The MS sickness rate was 15.693%, the NAFLD sickness rate of the MS group was higher than the non-MS group (χ2=99.171, P<0.001). (2) The NAFLD group`s values in BMI, FBG, SBP, DBP, TG, TC, LDL-C, ALT, and UA were all higher than that of the non-NAFLD group (P<0.001). Values in AST were higher than that of the non-NAFLD group (t=3.242, P=0.001), and values in HDL-C were lower than that of the non-NAFLD group (t=3.510, P<0.001); The NAFLD group`s incidence rates of overweight and obesity, hyperglycemia, hypertension, high TG, low HDL-C, hyperuricemia and MS were higher than that of the non-NAFLD group (P<0.001), abnormal rates of liver fuction were higher that the non-NAFLD group (t=10.119, P=0.002). (3) The sickness rates of NAFLD tended to rise with the increase of diagnostic items of MS diagnostic criteria (χ2=239.918, P<0.001). Conclusion MS was closely related to NAFLD and they had impact on each other.