修复运动性肌腱损伤组织工程化肌腱及种子细胞和支架材料

背景：获得大规模、具有再生活力的种子细胞以及具有与正常人体肌腱组织相接近的力学性能的理想支架材料是当前组织工程化肌腱研究面临的最为关键的限制性因素。 目的：总结和分析组织工程肌腱研究中的种子细胞和支架材料的研究进展。 方法：查阅近年来肌腱组织工程研究的相关文献，综合国内外最新研究成果，就肌腱组织工程中合适的种子细胞来源、研究更为理想的支架材料及组织相容性等方面的进展进行概述。 结果与结论：肌腱组织工程中常用的种子细胞有间充质干细胞、肌腱干细胞及胚胎干细胞等，可以向骨、软骨和脂肪分化，修复肌腱损伤的理想细胞。肌腱组织工程支架材料有天然材料及人工合成材料等，肌腱组织工程支架材料应有良好的生物相容性和适度的机械性能，复合材料将是肌腱组织工程支架材料研究的重点。 中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程 

Seed cells and scaffold materials for construction of tissue-engineered tendon to repair exercise-induced tendon injury

BACKGROUND: To harvest a large amount of seed cells with regenerative viability and ideal scaffold materials with mechanical properties similar to the human tendon is crucial for current tissue-engineered tendon research. OBJECTIVE: To summarize and analyze the progress in seed cells and scaffold materials for tissue-engineered tendon. METHODS: Literatures addressing tendon tissue engineering published in recent years were retrieved and combined with latest achievements to analyze the research progress in seed cell sources, ideal scaffold materials, and histocompatibility for tendon tissue engineering. RESULTS AND CONCLUSION: Commonly used seed cells for tendon tissue engineering include mesenchymal stem cells, tendon stem cells and embryonic stem cells, all of which are ideal cells that can differentiate to bone, cartilage and fat so as to repair damaged tendons. Tendon tissue engineering scaffolds are made of natural materials and synthetic materials, which should have good biocompatibility and appropriate mechanical properties. In the future, composite materials will be the research focus of tendon tissue engineering scaffold materials.