Immunocompetence of lymphocytes from pregnant mice studied in graft versus host reaction

The ability of lymphocytes taken during the second trimester from C57BL/6 mice mated with CBA males to induce the graft versus host reaction in (CBAxC57BL/6)F₁ hybrids was weaker than that of cells both of virgin donors and of mice pregnant after syngeneic mating. This was reflected in lengthening of the life span of the experimental recipients and weakening of inhibition of endogenous colony formation in the spleen of sublethally irradiated hybrids. This ability was restored at the end of pregnancy and in some experiments it actually exceeded the control.Department of Microbiology, Smolensk Medical Institute. (Presented by Academician of the Academy of Medical Sciences of the USSR N. N. Zhukov-Verezhnikov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 83, No. 3, pp. 310–312, March, 1977.