| 番茄红素改善D-半乳糖致衰大鼠抗氧化功能的研究 |
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| 引用本文： | 惠伯棣,裴凌鹏,刘沐霖. 番茄红素改善D-半乳糖致衰大鼠抗氧化功能的研究[J]. 中国药学杂志, 2008, 43(14): 1074-1077 |
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| 作者姓名： | 惠伯棣 裴凌鹏 刘沐霖 |
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| 作者单位： | 1.北京联合大学应用文理学院 北京 100083;2.中国中医科学院 北京 100700;3.新疆红帆科技生物有限公司 新疆巴州 841100 |
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| 基金项目： | 北京市自然科学基金对外合作项目 |
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| 摘 要： | 目的研究番茄红素对D-半乳糖致衰老大鼠抗氧化能力的影响、方法用D-半乳糖注射Wistar雄性大鼠5个月,建立衰老模型。对模型组、番茄红素组肝脏、肾脏、心脏、脑和前列腺等脏器丙二醛(MDA)含量、超氧化物歧化酶(SOD)、谷胱甘肽过氧化酶(GSH-Px)活性进行测定及比较。结果番茄红素组各脏器MDA含量均比模型组有显著降低(P<0.01),而SOD、GSH-Px酶活性比模型组有显著升高(P<0.01)。结论摄入适量番茄红素可以有效地增强大鼠机体抗氧化能力,从而延缓D-半乳糖诱发的大鼠衰老。
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| 关 键 词： | 丙二醛 超氧化物歧化酶 谷胱甘肽过氧化酶 番茄红素 |
| 收稿时间： | 2007-08-08; |
Effects of Lycopene on Antioxidation in D-galactose Induced Aged Rat |
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| HUI Bo-di,PEI Ling-peng,LIU Mu-lin. Effects of Lycopene on Antioxidation in D-galactose Induced Aged Rat[J]. Chinese Pharmaceutical Journal, 2008, 43(14): 1074-1077 |
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| Authors: | HUI Bo-di PEI Ling-peng LIU Mu-lin |
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| Affiliation: | 1.College of Applied Art & Science of Beijing Union University，Beijing 100083，China； 2.China Academy of Chinese Medicine Science，Beijing 100700，China； 3.Xinjiang TomatoRed Co.，Ltd of Biological Science and Technology，Bazhou 841100，China |
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| Abstract: | OBJECTIVE To investigate the influence of lycopene on the antioxidantive function of D-galactose induced aging rat. METHODS Wistar rats were given D-galactose for 5 months for developing the aging model.Then they were randomly divided in four groups,including model group,low-does lycopene group,middle-does lycopene group and high-does lycopene group.The content of malonic aldehyde(MDA)and the activity of superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)of different viscera (liver,kidney,heart,brain,prostate,et al)were determined.RESULTS Compared with model group,the content of MDA in the lycopene group were significantly decreased(P<0.01).However,the activity of SOD and GSH-Px was significantly increased(P<0.01).CONCLUSION Lycopene can increase antioxidantive function of rat and delay D-galactose induced consenescence. |
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| Keywords: | malonic aldehyde superoxide dismutase glutathione peroxidase lycopene |
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