| 茵陈蒿汤的发展及现代研究 |
| |
| 引用本文： | 慕永平,刘平,王磊.茵陈蒿汤的发展及现代研究[J].中国实验方剂学杂志,2006,12(2):67-71. |
| |
| 作者姓名： | 慕永平 刘平 王磊 |
| |
| 作者单位： | 上海中医药大学肝病研究所,上海,201203 |
| |
| 基金项目： | 上海市自然科学基金重点项目（No：02JC14024） |
| |
| 摘 要： | 综述了茵陈蒿汤的发展及研究现状，自仲景以来，历代将茵陈蒿汤化载用于治疗各类黄疸性疾病，现代研究表明，茵陈蒿汤不仅具有促进胆红素代谢的作用，还具有抗肝损伤，抑制肝细胞凋亡、抑制星状细胞活化及胶原合成等作用，其作用的物质基础主要为6，7-二甲基香豆素、都桷子素及大黄素等，并进一步明确了一些有效组分的作用靶点。
|
| 关 键 词： | 茵陈蒿汤 方剂 肝损伤 胆汁瘀积 |
| 文章编号： | 1005-9903（2006）02-0067-05 |
| 收稿时间： | 2004-12-21 |
| 修稿时间： | 2004年12月21 |
Evolution and Modern Research of Yinchenhao Decoction |
| |
| MU Yong-ping,LIU Ping,WANG Lei.Evolution and Modern Research of Yinchenhao Decoction[J].China Journal of Experimental Traditional Medical Formulae,2006,12(2):67-71. |
| |
| Authors: | MU Yong-ping LIU Ping WANG Lei |
| |
| Institution: | Institute of Liver Disease, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China |
| |
| Abstract: | Evolution and modem research of Yinchenhao Decoction were reviewed in this article. Yinchenhao Decoction had been modified to treat diseases with jaundice since the times of Zhang Zhong-jing in East Han dynasty. Modem research had validated the following pharmacologic effects of this herbal recipe as promoting bilirubin metabolism, auti-hepatic injury, inhibiting apoptosis of hepatocytes and collagen synthesis and inactivating hepatic stellate ceils. The substance basis for above effects involved 6,7-dimethylescutin, genipin and emodin, etc. In addition, several potential targets of these ingredients had also been verified. |
| |
| Keywords: | Yinchenhao Decoction recipe liver injury cholestasis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《中国实验方剂学杂志》浏览原始摘要信息 |
| 点击此处可从《中国实验方剂学杂志》下载免费的PDF全文 |
