益骨口服液对去势大鼠骨密度与骨生物力学的影响

[目的]探讨益骨口服液对实验去势大鼠骨密度和骨生物力学变化的影响。[方法]将大鼠随机分为A、B、C、D、E五组,A组(10只)为正常对照组(假手术);B组(10只)为模型组(造模后给予蒸馏水亦即空白组);C组(10只)为阳性对照组(切除双侧卵巢并予以倍美力治疗);D组(10只)为高浓度组(造模后给予含生药1.5g/ml益骨口服液治疗);E组(10只)为低浓度组(造模后给予含生药0.5g/ml益骨口服液治疗)。灌胃12周后,活杀各组动物,以双能X线测定骨密度及三点弯曲试验测生物力学指标。[结果]治疗组骨密度明显高于模型组(P0.05),骨生物力学性能较模型组得到明显改善(P0.05)。结论:益骨汤能促进骨形成,能提高骨强度及生物力学性能。

Effect of YiGu Oral Solution on Ovariectomized Rats' Bone Density and Biomechanics

[Objective] To observe the effect of YiGu Oral Solution on bone structure and bone biomechanics.[Methods]Rats were randomly divided into A,B,C,D,E five groups,A group（10）for the normal control group（sham operation）;B group（10）as a model group（distilled water model that is,after the blank group）;C group（10）for the positive control group（resection of bilateral ovarian and western medicine treatment Premarin）;D group（10）for the high concentration group（model after treatment with 1.5g/mlYiGu Oral Solution Pharmacognosy）;E group（10）for the low concentration group（model after treatment with 0.5g/mlYiGu Oral Solution pharmacognostic）.Twelve weeks after oral administration of live animals in each group to kill in order to dual-energy X-ray density of bone mineral density determination.[Results]BMD was significantly higher than the model group（P〈0.05）,than the mechanical properties of bone biology has marked improvement in the model group（P〈0.05）.[Conclusion] YiGu Oral Solution can promote bone formation and improve the mechanical properties of bone biology.