Extended HLA haplotypes in Japanese homozygous typing cells |
| |
| Authors: | T.K. Naruse Y. Nose R. Ando N. Araki A. Shigenari A. Ando M. Ishihara M. Kagiya N. Nabeya G. Isshiki H. Inoko |
| |
| Affiliation: | Department of Genetic Information, Division of Molecular Life Science, Tokai University School of Medicine, Isehara, Japan;Hyougo Red Cross Blood Center;Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Japan;Nabeya Clinic;Department of Pediatrics, Osaka City University School of Medicine, Osaka |
| |
| Abstract: | ![]()
Abstract: We have defined extended HLA haplotypes including the HLA class II genes, the non-HLA genes such as TAP1, TAP2 and LMP2, and the (CTG)n microsatellite repeats within the N0TCH4 gene between DRA and 21OH in 33 Japanese HLA homozygous typing cells (HTC). These conserved haplotypes characterized by unique linkage might be maintained as a result of functional co-operation among them in the antigen presentation pathway. These HTCs can be served as an original and ethnic-specific standard panel, providing useful genetic markers in haplotypic diversity, disease association, and anthropology studies. |
| |
| Keywords: | extended haplotypes HLA class II homozygous typing cells standard panel |
|
|
