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| 牛磺酸对体外冲击波碎石术致肾损伤保护的实验研究 | |
| 引用本文： | 朱伟,曾甫清,刘聪,何延瑜. 牛磺酸对体外冲击波碎石术致肾损伤保护的实验研究[J]. 华中科技大学学报(医学版), 2007, 36(5): 630-632,643 |
| 作者姓名： | 朱伟 曾甫清 刘聪 何延瑜 |
| 作者单位： | 1. 华中科技大学同济医学院附属协和医院泌尿外科,武汉,430022;福建医科大学临床医学院,福建省立医院泌尿外科,福州,350001 2. 华中科技大学同济医学院附属协和医院泌尿外科,武汉,430022 3. 华中科技大学同济医学院附属同济医院病理科,武汉,430030 4. 福建医科大学临床医学院,福建省立医院泌尿外科,福州,350001 |
| 摘 要： | 目的探讨牛磺酸在体外冲击波碎石术（ESWL）致肾损伤中的保护作用及机制。方法40只家兔随机分为：生理盐水对照组、牛磺酸组。分别测定ESWL前后外周血中损伤相关因子内皮素（ET-1）、丙二醛（MDA）及保护相关因子一氧化氮（NO）、超氧化物歧化酶（SOD）的含量。并观察肾脏组织形态及细胞超微结构变化。结果两组在ES-WL后外周血ET-1、MDA含量均升高,NO和SOD的含量则均降低,同期牛磺酸组ET-1、MDA升高幅度明显低于对照组,同期牛磺酸组SOD、NO降低幅度也明显低于对照组。结论牛磺酸可能通过减少肾组织氧自由基的产生,调节ET-1、NO水平之间平衡的机制,保护肾脏,缓解ESWL引起的肾脏损伤 |
| 关 键 词： | 牛磺酸 体外冲击波 碎石术 肾损伤 |
| 修稿时间： | 2006-04-12 |
The Protective Effects of Taurine on Shock Wave Lithotripsy-induced Kidney Injury in a Rabbit Model |
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| Zhu Wei , Zeng Fuqing , Liu Cong et al. The Protective Effects of Taurine on Shock Wave Lithotripsy-induced Kidney Injury in a Rabbit Model[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 2007, 36(5): 630-632,643 | |
| Authors: | Zhu Wei Zeng Fuqing Liu Cong et al |
| Affiliation: | 1Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022;2Department of Urology, Fujian Provincial Hospital, Fuzhou 350001;3 Department of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030 |
| Abstract: | Objective To study the protective effects of taurine on renal function damage induced by shock wave lithotripsy(ESWL).Methods Forty rabbits were randomly divided into two groups before ESWL:taurine-treated group and normal saline-treated group.The levels of plasma endothelin-1(ET-1),plasma nitric oxide(NO),superoxide dismutase(SOD) and serum alondialdehyde(MDA) before and after ESWL were determined.The ultrastructural and morphologic changes of renal tissues were observed under the light microscopy and electron microscopy.Results The levels of blood NO and SOD were decreased,while the levels of blood ET-1 and MDA were increased in both two groups after ESWL.The increases of SOD,MDA and the decreases of NO and ET-1 in the taurine-treated group were less than those in the normal saline-treated group.Conclusion Taurine may alleviate the damage to kidney due to ESWL by reducing the production of oxygen free radical and regulating the balance between ET-1 and NO. |
| Keywords: | taurine extracorporeal shock wave lithotripsy kidney injury |
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