不同声强8Hz次声作用对大鼠GSH-PX,SOD活性及MDA含量的影响

目的：观察不同声强的８Ｈｚ次声较长时间作用大鼠后，脑心肝肺的ＧＳＨ－ＰＸ，ＳＯＤ活性及ＭＤＡ含量的变化以探讨次声作用对组织细胞的影响．方法：用８Ｈｚ９０ｄＢ，１２０ｄＢ次声作用，每日２ｈ，１４ｄ后观察大鼠脑肝心肺组织中ＧＳＨ－ＰＸ活性，ＳＯＤ活性及ＭＤＡ含量的变化．结果：大鼠脑肝肺组织中ＧＳＨ－ＰＸ活性较对照组均有显著降低（Ｐ〈０．０５，Ｐ〈０．０１）．而心肌组织中ＧＳＨ－ＰＸ活性变化不明显．大鼠

Effects of 8 Hz infrasound with different intensity on glutathione peroxidase and superoxide dismutase activities and madlondialdehyde contents in rats

AIM: To explore the effects of infrasound on tissues and cells. METHODS: The rats were exposed 2 hours a day to infrasound of 8Hz with 90dB and 120dB for 14 days. The changes of glutathione peroxidase and superoxide dismutase activities and madlondialdehyde contents in the brain, heart, lung and liver of rats were observed. RESULTS: It was found that the activity of glutathione peroxidase (GSH PX) in the brain, lung and liver tissues of rats was lower in the exposed groups than that in the control group ( P< 0.05, P< 0.01). The changes of glutanthione peroxidase (GSH PX) in the heart tissues of rats showed no difference with those in the control group. The activity of superoxide dismutese (SOD) and malondialdehyde (MDA) contents in the brain and lung increased significantly ( P< 0.05, P< 0.01). The changes of superoxide dismutese and molondialdehyde contents in the liver and heart tissues of rats showed no difference. CONCLUSION: The results suggest that oxygen free radicals have increased after infrasound exposure, which may cause injury to the tissues and cells.