可溶性白细胞介素2受体与肝病关系的研究

用ELISA法检测了急慢性肝炎和肝炎后肝硬化的血清可溶性白细胞介素2受体（SIL－2R）水平。结果表明肝炎后肝硬化、急肝急性期、慢肝活动期均高于正常对照（P＜0．001）。急肝急性期与恢复期相比，慢肝活动期与稳定期相比差别均有显著性（P＜0．001）。慢肝恢复期和对照组相比差别亦有显著性。各型急肝之间差别无显著性。慢性乙肝血清SIL－2R含量与病毒复制无关。故认为SIL－2R可用于肝炎病情的监测、疗效观察和预后的判断。

Study on relation between soluble interleukin-2 receptor and hepatopathy

The levels of serum soluble interleukin-2 receptor(SIL-2R) of the patients ill with acute hepatitis (AH), chronic hepetitis (CH) and pethepatitic liver cirrhosis (PHLC) were detected by an enzymelinked immunosorbent assay(ELISA). The results indicated that the levels of serum SIL- 2R of all the patients in PHLC, AH acute stage and CH active stage were higher than the normal, control (NC) (P< 0. 001 ). Both comparing AH acute stage with convalescence and comparing CH acute stage with stationary phase, there were significant differences (P<0. 001 ). Comparing the level of CH convalescence with that of the control group, there was also a significant difference. There was no significant difference among the various types of AH, including type B, type non-A, non-B. The content of serum SIL-2R of chronic hepotitis B(CHB) didn' t relate to the virus replication. So it is considered that SIL-2R can be used to monitor patients condition, to observe therapeutic effectiveness and evaluate prognods of the patients ill with AH and CH.