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The efficacy and tolerability of divalproex sodium in elderly demented patients with behavioral disturbances
Authors:Mark E. Kunik  Lucy Puryear  Claudia A. Orengo  Victor Molinari  Richard H. Workman
Abstract:Behavioral disturbances are commonly encountered in elderly demented patients. The records of all patients admitted to a geropsychiatric inpatient unit within a 2-year period who had a primary diagnosis of dementia and an accompanying behavioral disturbance treated with divalproex sodium were reviewed. Of the 13 patients identified, all tolerated divalproex sodium without significant side-effects. General psychiatric symptoms, overall agitation, physical aggression and non-aggressive physical agitation decreased significantly, but verbal agitation did not. Divalproex sodium is well tolerated and may be effective in ameliorating certain behavioral disturbances in elderly demented patients with agitation. © 1998 John Wiley & Sons, Ltd.
Keywords:dementia  agitation  behavioral disturbance  geropsychiatry  psychotropic agent  side-effect profile
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