Effects of intrapallidal cannabinoids on rotational behavior in rats: Interactions with the dopaminergic system

The effect of unilateral intrapallidal cannabinoid receptor stimulation on rotational behavior in rats was explored. The potent cannabinoid agonist CP55,940 (5 μg/0.5 μl) induced ipsilateral turning when microinjected unilaterally into the globus pallidus. The D₂ dopamine agonist quinpirole reversed this ipsilateral rotation but failed to affect motor behavior on its own. Finally, the D₁ dopamine agonist SKF 82958 inhibited movement when administered into the globus pallidus, and this effect was not additive with CP55,940. Synapse 28:27–32, 1998. © 1998 Wiley-Liss, Inc.