Vogt-小柳-原田综合征Dalen-Fuchs结节的荧光素和吲哚青绿眼底血管造影分析

目的：探讨Vogt-小柳原田综合征（Vogt-Koyanagi-Harada syndrome,VKHS)Dalen-Fuchs结节的眼底表现及其临床意义。方法：对36例患者作了眼底彩色照相及荧光素眼底血管造影（fundus fluorescein angiography FFA)，其中6例同时作了吲哚青绿血管造影（indocyanine green angiography,ICGA)。结果：36例VKHS患者中，存在Dalen-Fuchs结节者16例（44．44％），类圆形黄色结节位于下方中周部者最多（93％），急性期的Dalen-Fuchs结节FFA后期结节染色，而ICGA呈边界清楚的弱荧光，恢复期的Dalen-Fuchs结节FFA和ICGA均显著结节下的脉络膜血管萎缩及RPE萎缩，色素增殖改变，ICGA显示的Dalen-Fuchs结节比眼底彩色照相和FFA要清晰。结论：Dalen-Fuchs结节是VKHS的一个重要临床特征表现，ICGA能更好显示这种结节样损害。

Analysis of fundus fluorescein angiography and indocyanine green angiography on Dalen- Fuchs nodules of Vogt- Koyanagi- Harada Syndrome

Objective: To investigate the fundus appearance and clinical value of Dalen-Fuchs nodules in Vogt-Koyanagi-Harada syndrome (VKHS). Methods: Thirty-six cases (72 eyes) of VKHS were examined with fundus color photograph and fundus fluorescein angiography (FFA). Indocyanine green angiography (ICGA) was performed in 6 cases (12 eyes). Results: In 36 case of VKHS. Dalen-Fuchs nodules were found to be present in 16 cases (44.44%). 93.8% of the Dalen-Fuchs nodules were distributed in the lower midperiphery. FFA showed that the Dalen-Fuchs nodules were hypo fluorescent in the early phases and late staining. ICGA revealed that the Dalen-Fuchs nodules were hypo fluorescent through the early phase to late phase. The Dalen-Fuchs nodules were showed better in ICGA than in FFA. Conclusions: Dalen-Fuchs nodule seems the important feature of VKHS, and ICGA is sensitive in delineating the lesions.