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An immunohistochemical study of MAP2 and clathrin in gerbil hippocampus after cerebral ischemia
Authors:Kenji Yoshimi   Masatoshi Takeda   Tsuyoshi Nishimura   Takashi Kudo   Yu Nakamura   Kunitoshi Tada  Nobuyoshi Iwata
Affiliation:

aNew Lead Research Laboratories, Sankyo Co., Ltd., Tokyo Japan

bDepartment of Neuropsychiatry, Osaka University Medical School, Osaka Japan

Abstract:Changes in MAP2 and clathrin immunoreactivity were studied in gerbil hippocampus after transient cerebral ischemia. MAP2 immuno-reactivity decreased significantly by 1 h in the subiculum-CA1 and CA2 areas which correspond to reactive change, while no decrease was observed in CA1 until day 4. Before the initiation of delayed neuronal death, MAP2 immunoreactivity was not changed in CA1. On the other hand clathrin immunoreactivity increased in the pyramidal cell layer of CA1 by 3 h after ischemia and remained high for 2 days. Clathrin immunoreactivity in the pyramidal cell layer of CA1 diminished after delayed neuronal death. The transient change of clathrin was noted especially in CA1 in the period prior to delayed neuronal death. These results imply an abnormal change in clathrin turnover after ischemia, which may participate in the pathogenesis of delayed neuronal death.
Keywords:Clathrin   Microtubule-associated protein 2   Cerebral ischemia   Hippocampus   Delayed neuronal death   Gerbil
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