托盘根水煎剂降糖作用分析

目的:探讨托盘根水煎剂对四氧嘧啶诱导的糖尿病大鼠的降糖作用。方法:Wistar大鼠80只,采用大鼠尾静脉注射四氧嘧啶复制糖尿病大鼠模型。随机分为模型组(ig 13.5 m L·kg-1的蒸馏水),阳性药组(210 mg·kg-1的盐酸二甲双胍水溶液),托盘根低、高剂量组(分别ig 1.35,2.70 g·kg-1托盘根水煎剂),另设正常组,每组10只,每天ig 1次,共13 d。检测空腹血糖(FBG),一氧化氮(NO),丙二醛(MDA),超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)及脏器系数的影响。结果:与正常组比较,模型组FBG,SOD,GSH-Px水平明显升高,NO,MDA含量明显降低(P0.05);经托盘根治疗后,治疗组FBG水平较模型组降低(P0.05),低剂量组血清中NO和高剂量组血清中MDA含量较模型组升高(P0.05),而高剂量组血清中SOD和低、高剂量组血清中GSH-Px含量较模型组降低(P0.05),且托盘根水煎剂对所取脏器均有修复作用。结论:托盘根水煎剂可通过增强机体的抗氧化作用,促进胰岛功能恢复而发挥降血糖作用。

Anti-hyperglycemic Effect of Rubus crataegiflolius Roots Decoction

Objective: To observe the anti-hyperglycemic effect of the decoction of Rubus crataegiflolius roots in diabetic rats induced by alloxan. Method: Diabetic rat models were copied by iv alloxan through tail vein, then rats were randomly divided into 4 groups;the model group (distilled water, 13.5 mL·kg^-1), the positive control group (metformin hydrochloride,210 mg·kg^-1), the low and high dose groups (decoction of R. crataegifloliums roots, 1.35, 2.70 g·kg^-1) of 10 rats each. Another 10 healthy rats were assigned to the normal group (distilled water, 13.5 mL·kg^-1). The corresponding medicines were intragastrically administrated to rats once daily for 13 days. Changes of fasting blood-glucose (FBG), nitrogen oxide (NO), malonaldehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were detected. The organ coefficient was calculated. Result: Compared with the normal group, the levels of FBG, SOD and GSH-Px increased, the levels of NO and MDA decreased in the model group (P<0.05). Compared with model group, the levels of FBG and GSH-Px decreased in the low and high dose groups (P<0.05), the NO level increased in the low dose group (P<0.05), the MDA levels increased in the high dose group (P<0.05), and the SOD level decreased in the high dose group (P<0.05). Moreover, the organ damage could be repaired by R. crataegifldiums roots decoction. Conclusion: R. crataegiflolius roots decoction could decrease blood glucose by improving the anti-oxidation function of the body and the functional recovery of the isle.