纳米二氧化钛神经毒性的研究进展

纳米二氧化钛（TiO₂ NPs）能屏蔽紫外线，是一种具有良好分散性和耐候性的白色疏松粉末，常作为新型纳米材料应用于化妆品、功能纤维、塑料、涂料、油漆等行业，因此可从呼吸道、消化道、皮肤接触等多种途径进入人体。近年来，随着TiO₂ NPs在各领域的应用，其安全性和其潜在危害逐渐得到了人们的关注和重视。该文结合目前TiO2 NPs神经毒性的各类相关研究，从其理化性质、暴露途径和神经毒性机制方面对TiO₂ NPs的安全性进行评价，并进行讨论、总结与展望。

Research advance in the neurotoxicity of titanium dioxide nanoparticles

Titanium dioxide nanoparticles are white loose powder with superior ultraviolet-shielding effect, dispersibility and weather resistance. They are often applied as a novel nano-material in the production of cosmetics, functional fibers, plastics, coatings and paints, and may therefore enter the human body through the respiratory tract, digestive tract or skin contact. In recent years, with the extended application of titanium dioxide nanoparticles in various industries, the safety and potential harm of titanium dioxide nanoparticles have attracted great attentions. This article evaluates the safety of titanium dioxide nanoparticles from the perspective of physicochemical properties, exposure pathways and the mechanisms of neurotoxicity based on currently available studies. In addition, the research progress and the prospects of titanium dioxide nanoparticles are discussed.